A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans.
b2/b3 deletions
complex structural rearrangements
daz, bpy2, cdy1 dosage
evolutionary biology
genetics
genomics
gr/gr
human
idiopathic male infertility
variants
y haplogroup r1a1-m458
y-chromosomal azfc region
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 03 2021
30 03 2021
Historique:
received:
03
12
2020
accepted:
15
03
2021
entrez:
30
3
2021
pubmed:
31
3
2021
medline:
11
9
2021
Statut:
epublish
Résumé
Male infertility is a prevalent condition, affecting 5-10% of men. So far, few genetic factors have been described as contributors to spermatogenic failure. Here, we report the first re-sequencing study of the Y-chromosomal
Identifiants
pubmed: 33781384
doi: 10.7554/eLife.65420
pii: 65420
pmc: PMC8009663
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Estonian Research Council
ID : IUT34-12
Organisme : Estonian Research Council
ID : IUT24-1
Organisme : Estonian Research Council
ID : PUT181
Organisme : European Regional Development Fund
ID : 3.2.0701.12-004
Organisme : Estonian Research Council
ID : PUT1036
Organisme : Estonian Research Council
ID : PRG1021
Organisme : Wellcome Trust
ID : 098051
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Estonian Research Council
ID : MOBTT53
Informations de copyright
© 2021, Hallast et al.
Déclaration de conflit d'intérêts
PH, LK, MP, EA, SR, MG, RF, MJ, OP, KP, PK, KR, YX, CT, ML No competing interests declared
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