Expression and Cell Type-specific Localization of Inflammasome Sensors in the Spinal Cord of SOD1

Amyotrophic Lateral Sclerosis / genetics Animals Caspase 1 Humans Inflammasomes Mice Spinal Cord Superoxide Dismutase-1 / genetics
AIM2 ASC NLRC4 NLRP1 PRR amyotrophic lateral sclerosis

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
21 05 2021
Historique:
received: 14 10 2020
revised: 17 02 2021
accepted: 17 03 2021
pubmed: 31 3 2021
medline: 20 5 2021
entrez: 30 3 2021
Statut: ppublish

Résumé

Inflammasomes are key components of the innate immune system and activation of these multiprotein platforms is a crucial event in the etiopathology of amyotrophic lateral sclerosis (ALS). Inflammasomes consist of a pattern recognition receptor (PRR), the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) and caspase 1. Exogenous or endogenous "danger signals" can trigger inflammasome assembly and promote maturation and release of pro-inflammatory cytokines, including interleukin 1β. Previous studies have demonstrated presence and activation of NLRP3 in spinal cord tissue from SOD1

Identifiants

DOI: 10.1016/j.neuroscience.2021.03.023 PMID: 33781799
pubmed: 33781799
pii: S0306-4522(21)00156-1
doi: 10.1016/j.neuroscience.2021.03.023
pii:
doi:

Substances chimiques

Inflammasomes 0
SOD1 protein, human 0
Superoxide Dismutase-1 EC 1.15.1.1
Caspase 1 EC 3.4.22.36

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

288-302

Informations de copyright

Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

Auteurs

Carmen Hummel (C)

Institute of Neuroanatomy, RWTH Aachen University, Wendlingweg 2, Aachen, Germany.

Omid Leylamian (O)

Institute of Neuroanatomy, RWTH Aachen University, Wendlingweg 2, Aachen, Germany.

Anna Pösch (A)

Institute of Neuroanatomy, RWTH Aachen University, Wendlingweg 2, Aachen, Germany.

Joachim Weis (J)

Institute of Neuropathology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany.

Eleonora Aronica (E)

Amsterdam UMC, University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, the Netherlands.

Cordian Beyer (C)

Institute of Neuroanatomy, RWTH Aachen University, Wendlingweg 2, Aachen, Germany.

Sonja Johann (S)

Institute of Neuroanatomy, RWTH Aachen University, Wendlingweg 2, Aachen, Germany; Center of Experimental Medicine, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg, Germany. Electronic address: s.johann@uke.de.

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Eucaryotes › Animaux › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases initiatrices › Caspase-1 › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Expression and Cell Type-specific Localization...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Expression and Cell Type-specific Localization...