Feasibility and reliability of sequential logic with gene regulatory networks.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
10
2020
accepted:
14
03
2021
entrez:
30
3
2021
pubmed:
31
3
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Gene regulatory networks exhibiting Boolean behaviour, e.g. AND, OR or XOR, have been routinely designed for years. However, achieving more sophisticated functions, such as control or computation, usually requires sequential circuits or so-called state machines. For such a circuit, outputs depend both on inputs and the current state of the system. Although it is still possible to design such circuits by analogy with digital electronics, some particularities of biology make the task trickier. The impact of two of them, namely the stochasticity of biological processes and the inhomogeneity in the response of regulation mechanisms, are assessed in this paper. Numerical simulations performed in two use cases point out high risks of malfunctions even for designed GRNs functional from a theoretical point of view. Several solutions to improve reliability of such systems are also discussed.
Identifiants
pubmed: 33784367
doi: 10.1371/journal.pone.0249234
pii: PONE-D-20-33336
pmc: PMC8009411
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0249234Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist
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