Tailored Mobility in a Zeolite Imidazolate Framework (ZIF) Antibody Conjugate*.
antibodies
immunoassays
metal-organic frameworks
nanoparticles
zeolite analogues
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
25 Jun 2021
25 Jun 2021
Historique:
received:
03
03
2021
pubmed:
1
4
2021
medline:
1
7
2021
entrez:
31
3
2021
Statut:
ppublish
Résumé
Zeolitic imidazolate framework (ZIF) hybrid fluorescent nanoparticles and ZIF antibody conjugates have been synthesized, characterized, and employed in lateral-flow immunoassay (LFIA). The bright fluorescence of the conjugates and the possibility to tailor their mobility gives a huge potential for diagnostic assays. An enzyme-linked immunosorbent assay (ELISA) with horseradish peroxidase (HRP) as label, proved the integrity, stability, and dispersibility of the antibody conjugates, LC-MS/MS provided evidence that a covalent link was established between these metal-organic frameworks and lysine residues in IgG antibodies.
Identifiants
pubmed: 33786901
doi: 10.1002/chem.202100803
pmc: PMC8362128
doi:
Substances chimiques
Metal-Organic Frameworks
0
Zeolites
1318-02-1
Horseradish Peroxidase
EC 1.11.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9414-9421Informations de copyright
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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