Fontan-Associated Dyslipidemia.
Adult
Biomarkers
/ blood
Cholesterol
/ blood
Dyslipidemias
/ blood
Female
Follow-Up Studies
Fontan Procedure
/ adverse effects
Heart Defects, Congenital
/ blood
Humans
Incidence
Male
Middle Aged
Postoperative Complications
/ blood
Prognosis
Prospective Studies
United States
/ epidemiology
Young Adult
Fontan
adult congenital heart disease
high‐density lipoprotein cholesterol
lipids
single ventricle
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
06 04 2021
06 04 2021
Historique:
pubmed:
1
4
2021
medline:
19
2
2022
entrez:
31
3
2021
Statut:
ppublish
Résumé
Background Hypocholesterolemia is a marker of liver disease, and patients with a Fontan circulation may have hypocholesterolemia secondary to Fontan-associated liver disease or inflammation. We investigated circulating lipids in adults with a Fontan circulation and assessed the associations with clinical characteristics and adverse events. Methods and Results We enrolled 164 outpatients with a Fontan circulation, aged ≥18 years, in the Boston Adult Congenital Heart Disease Biobank and compared them with 81 healthy controls. The outcome was a combined outcome of nonelective cardiovascular hospitalization or death. Participants with a Fontan (median age, 30.3 [interquartile range, 22.8-34.3 years], 42% women) had lower total cholesterol (149.0±30.1 mg/dL versus 190.8±41.4 mg/dL,
Identifiants
pubmed: 33787283
doi: 10.1161/JAHA.120.019578
pmc: PMC8174355
doi:
Substances chimiques
Biomarkers
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e019578Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
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