Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study.
ARNTL Transcription Factors
/ blood
Adult
Blood Pressure
Circadian Rhythm
/ genetics
Cross-Sectional Studies
Female
Gene Expression
Glycated Hemoglobin
/ analysis
Hospitals
Humans
Inflammation
Leukocyte Count
Leukocytes, Mononuclear
/ chemistry
Male
Middle Aged
Nuclear Receptor Subfamily 1, Group D, Member 1
/ blood
Nurses
RNA
/ blood
Shift Work Schedule
Sleep
/ physiology
Circadian
Diabetes
Insulin resistance
Obesity
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
30
11
2020
accepted:
09
01
2021
pubmed:
1
4
2021
medline:
17
7
2021
entrez:
31
3
2021
Statut:
ppublish
Résumé
To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms. We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock. Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p < 0.001 for both), PSQI global score (p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p < 0.001). We demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression.
Identifiants
pubmed: 33788000
doi: 10.1007/s00592-021-01676-z
pii: 10.1007/s00592-021-01676-z
pmc: PMC8272695
doi:
Substances chimiques
ARNTL Transcription Factors
0
BMAL1 protein, human
0
Glycated Hemoglobin A
0
NR1D1 protein, human
0
Nuclear Receptor Subfamily 1, Group D, Member 1
0
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1111-1117Subventions
Organisme : European Union's Seventh Framework Programme
ID : 278397
Organisme : Deutsche Forschungsgemeinschaft
ID : TTR 219
Informations de copyright
© 2021. The Author(s).
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