Rabies virus glycoprotein enhances spatial memory via the PDZ binding motif.
Animals
Avoidance Learning
CA1 Region, Hippocampal
/ metabolism
Gene Expression
Genes, Reporter
Genetic Vectors
/ chemistry
Glycoproteins
/ genetics
Green Fluorescent Proteins
/ genetics
Injections, Intraventricular
Lentivirus
/ genetics
Male
Maze Learning
Neurons
/ metabolism
Rabies virus
/ chemistry
Rats
Rats, Wistar
Recombinant Fusion Proteins
/ genetics
Spatial Memory
Stereotaxic Techniques
Transgenes
Viral Proteins
/ genetics
CA1
Dorsal hippocampus
Learning and memory
PDZ binding motif
Rabies glycoprotein
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
06
07
2020
accepted:
17
03
2021
revised:
09
03
2021
pubmed:
1
4
2021
medline:
22
1
2022
entrez:
31
3
2021
Statut:
ppublish
Résumé
Rabies is a life-threatening viral infection of the brain. Rabies virus (RABV) merely infects excitable cells including neurons provoking drastic behaviors including negative emotional memories. RABV glycoprotein (RVG) plays a critical role in RABV pathogenesis. RVG interacts with various cytoplasmic PDZ (PSD-95/Dlg/ZO-1) containing proteins through its PDZ binding motif (PBM). PTZ domains have crucial role in formation and function of signal transduction. Hippocampus is one of the cerebral regions that contain high load of viral antigens. We examined impact of RVG expression in the dorsal hippocampus on aversive as well as spatial learning and memory performance in rats. Two microliter of the lentiviral vector (~10
Identifiants
pubmed: 33788140
doi: 10.1007/s13365-021-00972-2
pii: 10.1007/s13365-021-00972-2
doi:
Substances chimiques
Glycoproteins
0
Recombinant Fusion Proteins
0
Viral Proteins
0
Green Fluorescent Proteins
147336-22-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
434-443Subventions
Organisme : Pasteur Institute of Iran
ID : 868
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