Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors.

Antineoplastic Agents / chemical synthesis Dose-Response Relationship, Drug Drug Design HCT116 Cells Hep G2 Cells Humans Inhibitory Concentration 50 MCF-7 Cells Molecular Docking Simulation Neoplasms / drug therapy Protein Kinase Inhibitors / chemical synthesis Sorafenib / pharmacology Structure-Activity Relationship Thiazolidinediones / chemical synthesis Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
HCT-116 HepG2 MCF-7 VEGFR-2 inhibitors anticancer agents molecular docking thiazolidine-2,4-dione

Journal

Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167

Informations de publication

Date de publication:
Jul 2021
Historique:
revised: 23 02 2021
received: 28 12 2020
accepted: 26 02 2021
pubmed: 1 4 2021
medline: 15 12 2021
entrez: 31 3 2021
Statut: ppublish

Résumé

The anticancer activity of novel thiazolidine-2,4-diones was evaluated against HepG2, HCT-116, and MCF-7 cells. Among the tested cancer cell lines, HCT-116 was the most sensitive one to the cytotoxic effect of the new derivatives. In particular, compounds 18, 11, and 10 were found to be the most potent derivatives among all the tested compounds against the HepG2, HCT-116, and MCF-7 cancer cell lines, with IC

Identifiants

DOI: 10.1002/ardp.202000491 PMID: 33788290
pubmed: 33788290
doi: 10.1002/ardp.202000491
doi:

Substances chimiques

Antineoplastic Agents 0
Protein Kinase Inhibitors 0
Thiazolidinediones 0
thiazolidine-2,4-dione 0
Sorafenib 9ZOQ3TZI87
KDR protein, human EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2 EC 2.7.10.1

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2000491

Informations de copyright

© 2021 Deutsche Pharmazeutische Gesellschaft.

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Auteurs

Khaled El-Adl (K)

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, El-Salam City, Cairo, Egypt.
ORCID: 0000-0002-8922-9770

Helmy Sakr (H)

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.

Sanadelaslam S A El-Hddad (SSA)

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.

Abdel-Ghany A El-Helby (AA)

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.

Mohamed Nasser (M)

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.

Hamada S Abulkhair (HS)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt.
ORCID: 0000-0001-6479-4573

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