Report from the CVOT Summit 2020: new cardiovascular and renal outcomes.
COVID-19
/ epidemiology
Cardiovascular Diseases
/ epidemiology
Clinical Trials as Topic
/ methods
Congresses as Topic
/ trends
Diabetes Mellitus, Type 2
/ epidemiology
Humans
Kidney
/ drug effects
Mineralocorticoid Receptor Antagonists
/ administration & dosage
Renal Insufficiency, Chronic
/ epidemiology
Research Report
/ trends
Sodium-Glucose Transporter 2 Inhibitors
/ administration & dosage
Treatment Outcome
Cardiovascular disease
Chronic kidney disease
DAPA-CKD
Diabetes
EMPEROR-Reduced
FIDELIO-DKD
GLP-1 receptor agonist
Heart failure
Mineralocorticoid receptor antagonist
Obesity
SGLT2i inhibitor
VERTIS-CV
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
31 03 2021
31 03 2021
Historique:
received:
19
02
2021
accepted:
26
02
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
14
4
2021
Statut:
epublish
Résumé
The 6th Cardiovascular Outcome Trial (CVOT) Summit "Cardiovascular and Renal Outcomes 2020" was the first to be held virtually on October 29-30, 2020. As in previous years, this summit served as reference meeting for in-depth discussions on the topic of recently completed and presented major outcome trials. This year, focus was placed on the outcomes of VERTIS-CV, EMPEROR-Reduced, DAPA-CKD, and FIDELIO-DKD. Trial implications for diabetes management and the impact on new treatment algorithms were highlighted for diabetologists, cardiologists, endocrinologists, nephrologists, and general practitioners. Discussion evolved from major outcome trials using SGLT-2 inhibitors for treatment and prevention of heart failure and chronic kidney disease in people with and without diabetes, to additional therapy options for chronic kidney disease with a novel mineralocorticoid receptor antagonist. Furthermore, challenges in diabetes management like COVID-19 and obesity, as well as novel treatment strategies and guidelines, were discussed.The 7th Cardiovascular Outcome Trial Summit will be held virtually on November, 18-19, 2021 ( http://www.cvot.org ).
Identifiants
pubmed: 33789663
doi: 10.1186/s12933-021-01254-1
pii: 10.1186/s12933-021-01254-1
pmc: PMC8010779
doi:
Substances chimiques
Mineralocorticoid Receptor Antagonists
0
Sodium-Glucose Transporter 2 Inhibitors
0
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
75Références
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
N Engl J Med. 2020 Oct 8;383(15):1436-1446
pubmed: 32970396
Diabetes Care. 2015 Jan;38(1):140-9
pubmed: 25538310
JAMA. 2019 Sep 24;322(12):1155-1166
pubmed: 31536101
Cardiovasc Diabetol. 2016 Feb 18;15:33
pubmed: 26892706
Diabetes Res Clin Pract. 2020 Aug;166:108091
pubmed: 32105769
N Engl J Med. 2013 Oct 3;369(14):1327-35
pubmed: 23992602
N Engl J Med. 2019 Jan 24;380(4):347-357
pubmed: 30415602
J Am Coll Cardiol. 2019 Apr 2;73(12):1596-1598
pubmed: 30922481
Circulation. 2019 Apr 23;139(17):2022-2031
pubmed: 30786725
Lancet. 2018 Oct 27;392(10157):1519-1529
pubmed: 30291013
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Diabetes Care. 2020 Jul;43(7):1427-1432
pubmed: 32409501
Expert Opin Drug Saf. 2014 Jun;13(6):831-41
pubmed: 24766397
MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):458-464
pubmed: 32298251
Eur Heart J. 2020 Jan 7;41(2):255-323
pubmed: 31497854
Kidney Int. 2017 Aug;92(2):388-396
pubmed: 28577854
N Engl J Med. 2020 Oct 8;383(15):1413-1424
pubmed: 32865377
Lancet. 2018 Feb 10;391(10120):541-551
pubmed: 29221645
N Engl J Med. 2019 Aug 29;381(9):841-851
pubmed: 31185157
N Engl J Med. 2016 Nov 10;375(19):1834-1844
pubmed: 27633186
JAMA Cardiol. 2021 Feb 1;6(2):148-158
pubmed: 33031522
Circulation. 2021 Jan 26;143(4):337-349
pubmed: 33175585
Diabetes Res Clin Pract. 2019 Nov;157:107843
pubmed: 31518657
N Engl J Med. 2017 Aug 17;377(7):644-657
pubmed: 28605608
N Engl J Med. 2013 Oct 3;369(14):1317-26
pubmed: 23992601
Diabetologia. 2020 Feb;63(2):221-228
pubmed: 31853556
Cardiovasc Diabetol. 2020 Jul 20;19(1):114
pubmed: 32690029
Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2032-2045
pubmed: 28522654
N Engl J Med. 2019 Jun 13;380(24):2295-2306
pubmed: 30990260
J Clin Epidemiol. 2017 Nov;91:47-53
pubmed: 28911999
N Engl J Med. 2015 Nov 26;373(22):2117-28
pubmed: 26378978
Lancet. 2016 Apr 2;387(10026):1377-1396
pubmed: 27115820
Cardiovasc Diabetol. 2017 Mar 11;16(1):35
pubmed: 28284218
J Am Coll Cardiol. 2018 Dec 18;72(24):3200-3223
pubmed: 30497881
Circulation. 2019 Aug 27;140(9):739-750
pubmed: 31291786
Lancet Diabetes Endocrinol. 2018 Feb;6(2):105-113
pubmed: 29221659
Lancet. 2020 Sep 19;396(10254):819-829
pubmed: 32877652
J Physiol. 2014 Sep 15;592(18):3997-4012
pubmed: 24907306
Hypertension. 2015 Feb;65(2):257-63
pubmed: 25368026
Cardiovasc Diabetol. 2018 Feb 19;17(1):30
pubmed: 29458368
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
Cardiovasc Diabetol. 2019 Mar 11;18(1):30
pubmed: 30857522
JAMA. 2019 Jan 1;321(1):69-79
pubmed: 30418475
Lancet Diabetes Endocrinol. 2019 Oct;7(10):776-785
pubmed: 31422062
N Engl J Med. 2020 Dec 03;383(23):2219-2229
pubmed: 33264825
Cardiovasc Diabetol. 2018 Jun 8;17(1):83
pubmed: 29884191
Lancet. 2019 Jul 13;394(10193):121-130
pubmed: 31189511
Nat Rev Endocrinol. 2019 May;15(5):288-298
pubmed: 30814686
J Clin Epidemiol. 2017 Nov;91:23-30
pubmed: 28912002
N Engl J Med. 2021 Jan 14;384(2):117-128
pubmed: 33200892
Metabolism. 2020 Dec;113:154378
pubmed: 33002478
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Handb Exp Pharmacol. 2017;243:271-305
pubmed: 27830348
Lancet. 2017 Apr 8;389(10077):1399-1409
pubmed: 28237263
Cardiovasc Diabetol. 2020 Apr 17;19(1):47
pubmed: 32303223
Obesity (Silver Spring). 2020 Jun;28(6):1050-1061
pubmed: 32441473
N Engl J Med. 2020 Oct 8;383(15):1425-1435
pubmed: 32966714
Lancet. 2019 Jul 13;394(10193):131-138
pubmed: 31189509
JAMA Surg. 2014 Mar;149(3):275-87
pubmed: 24352617
N Engl J Med. 2016 Jul 28;375(4):311-22
pubmed: 27295427
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27
pubmed: 29222373
Circulation. 2020 Dec 8;142(23):2205-2215
pubmed: 33026243
N Engl J Med. 2019 Nov 21;381(21):1995-2008
pubmed: 31535829
Diabetes Care. 2020 Feb;43(2):487-493
pubmed: 31857443
Indian J Endocrinol Metab. 2011 Apr;15(2):99-104
pubmed: 21731866
N Engl J Med. 2021 Jan 14;384(2):129-139
pubmed: 33200891
N Engl J Med. 2015 Dec 3;373(23):2247-57
pubmed: 26630143
N Engl J Med. 2017 Sep 28;377(13):1228-1239
pubmed: 28910237
Lancet. 2019 May 11;393(10184):1937-1947
pubmed: 30995972
Nat Med. 2019 May;25(5):805-813
pubmed: 31011203
Expert Opin Investig Drugs. 2015;24(8):1123-35
pubmed: 26095025
Am J Kidney Dis. 2014 Oct;64(4):510-33
pubmed: 25257325
N Engl J Med. 2015 Jul 16;373(3):232-42
pubmed: 26052984
Eur J Prev Cardiol. 2019 Dec;26(2_suppl):7-14
pubmed: 31766915
Prim Care Diabetes. 2021 Feb;15(1):31-51
pubmed: 32532635
Eur J Prev Cardiol. 2020 Mar 25;:
pubmed: 33611354
Cardiovasc Res. 2020 Aug 1;116(10):1666-1687
pubmed: 32352535