Maternal and neonatal outcomes of pregnancies complicated by late fetal growth restriction undergoing induction of labor with dinoprostone compared with cervical balloon: A retrospective, international study.
Administration, Intravaginal
Adult
Catheterization
/ methods
Cesarean Section
/ methods
Cohort Studies
Dinoprostone
/ adverse effects
Female
Fetal Growth Retardation
/ therapy
Humans
Infant, Newborn
Italy
Labor, Induced
/ methods
Oxytocics
/ adverse effects
Pregnancy
Pregnancy Outcome
Spain
Urinary Catheterization
/ methods
Cook balloon catheter
Foley balloon catheter
dinoprostone
fetal growth restriction
induction of labor
late fetal growth restriction
mechanical induction
prostaglandins
Journal
Acta obstetricia et gynecologica Scandinavica
ISSN: 1600-0412
Titre abrégé: Acta Obstet Gynecol Scand
Pays: United States
ID NLM: 0370343
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
06
02
2021
received:
03
12
2020
accepted:
09
02
2021
pubmed:
2
4
2021
medline:
28
8
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
The aim of this study was to compare vaginal dinoprostone and mechanical methods for induction of labor (IOL) in pregnancies complicated by late fetal growth restriction. Multicenter, retrospective, cohort study involving six referral centers in Italy and Spain. Inclusion criteria were pregnancies complicated by late fetal growth restriction as defined by Delphi consensus criteria. The primary outcome was the occurrence of uterine tachysystole; secondary outcomes were either cesarean delivery or operative vaginal delivery for non-reassuring fetal status, a composite score of adverse neonatal outcome and admission to neonatal intensive care unit (NICU). Univariate and multivariate logistic regression analysis was used to analyze the data. A total of 571 pregnancies complicated by late fetal growth restriction undergoing IOL (391 with dinoprostone and 180 with mechanical methods) were included in the analysis. The incidence of uterine tachysystole (19.2% vs. 5.6%; p = 0.001) was higher in women undergoing IOL with dinoprostone than in those undergoing IOL with mechanical methods. Similarly, the incidence of cesarean delivery or operative delivery for non-reassuring fetal status (25.6% vs. 17.2%; p = 0.027), composite adverse neonatal outcome (26.1% vs. 16.7%; p = 0.013) and NICU admission (16.9% vs. 5.6%; p < 0.001) was higher in women undergoing IOL with dinoprostone than in those undergoing IOL with mechanical methods. At logistic regression analysis, IOL with mechanical methods was associated with a significantly lower risk of uterine tachysystole (odds ratio 0.26, 95% confidence interval 0.13-0.54; p < 0.001). In pregnancies complicated by late fetal growth restriction, IOL with mechanical methods is associated with a lower risk of uterine tachysystole, cesarean delivery or operative delivery for non-reassuring fetal status, and adverse neonatal outcome compared with pharmacological methods.
Substances chimiques
Oxytocics
0
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1313-1321Investigateurs
Daniele Di Mascio
(D)
Cecilia Villalain
(C)
Danilo Buca
(D)
Ignacio Herraiz
(I)
Giuseppe Rizzo
(G)
Jose Morales-Rossello
(J)
Gabriela Loscalzo
(G)
Filomena G Sileo
(FG)
Alessandra Finarelli
(A)
Emma Bertucci
(E)
Fabio Facchinetti
(F)
Roberto Brunelli
(R)
Antonella Giancotti
(A)
Ludovico Muzii
(L)
Giuseppe M Maruotti
(GM)
Luigi Carbone
(L)
Gabriele Saccone
(G)
Alice D'Amico
(A)
Sara Tinari
(S)
Chiara Cerra
(C)
Federico Prefumo
(F)
Luigi Nappi
(L)
Pantaleo Greco
(P)
Rossella Monaci
(R)
Anna Fichera
(A)
Nicola Fratelli
(N)
Marco Liberati
(M)
Alberto Galindo
(A)
Francesco D'Antonio
(F)
Informations de copyright
© 2021 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).
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