Long-term stiripentol administration, an anticonvulsant drug, does not impair sperm parameters in rats.
anti-epileptic drug
hormones
rat
semen
stiripentol
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
25
01
2021
received:
29
07
2020
accepted:
09
03
2021
pubmed:
2
4
2021
medline:
22
6
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
In this study, we investigated the influence of long-term administration of stiripentol on sex hormones and semen quality in young Wistar rats. Investigated animals received for 6 months either stiripentol or saline solution. After one month, stiripentol increased temporarily serum level of testosterone (p < 0.05) and FSH (p < 0.01). However, after 6 months levels of testosterone, FSH, LH, prolactin and SHBG were comparable in both groups. After 6 months, semen analysis did not reveal differences in sperm concentration, total sperm count and sperm motility between groups. However, stiripentol increased the rate of head defect (p < 0.001) and midpiece abnormalities (p < 0.05). Flow cytometry revealed higher percentage of live cells without lipid peroxidation (p < 0.00001) and higher percentage of live spermatozoa with intact acrosomes (p < 0.000001) in rats receiving stiripentol. There was no significant difference between groups in sperm mitochondrial activity and DNA fragmentation index. However, percentage of high DNA stainability cells was increased in stiripentol group (p < 0.001). The data showed that stiripentol does not cause obvious disturbances in young rat's semen. Detected changes in semen morphology and chromatin structure need further explanation, and their influence on rat's fertility should be evaluated.
Substances chimiques
Anticonvulsants
0
Dioxolanes
0
Testosterone
3XMK78S47O
Follicle Stimulating Hormone
9002-68-0
stiripentol
R02XOT8V8I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14058Subventions
Organisme : Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
ID : SUB.A080.19.024
Informations de copyright
© 2021 Wiley-VCH GmbH.
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