Apigenin enhances viability of random skin flaps by activating autophagy.
angiogenesis
apigenin
apoptosis
autophagy
oxidative stress
random skin flaps
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
18
01
2021
received:
14
11
2020
accepted:
12
02
2021
pubmed:
2
4
2021
medline:
28
9
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
Random skin flap is widely used in plastic surgery. However, flap necrosis caused by ischemia-reperfusion injury limits its clinical applications. Apigenin, a naturally occurring flavonoid mainly derived from plants, facilitates flap survival. In this study, we explored the effects of apigenin on flap survival and the underlying mechanisms. A total of 54 mice having a dorsal random flap model were randomly divided into control, apigenin, and apigenin +3-methyladenine groups. These groups were treated with dimethyl sulfoxide solution, apigenin, and apigenin +3-methyladenine, respectively. The animals were then euthanized to assess angiogenesis, apoptosis, oxidative stress, and autophagy levels through histological and protein analyses. Apigenin promotes survival of the skin flap area and reduces tissue edema. In addition, apigenin enhanced angiogenesis, attenuated apoptosis, alleviated oxidative stress, and activated autophagy. Interestingly, 3-methyladenine reversed the effects of apigenin on flap survival, angiogenesis, apoptosis, and oxidative stress through inhibition of autophagy. The findings of this study show that apigenin promotes angiogenesis, inhibits cell apoptosis, and lowers oxidative stress by mediating autophagy, thus the improving survival rate of random skin flaps.
Substances chimiques
Angiogenesis Inducing Agents
0
Apigenin
7V515PI7F6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3848-3860Subventions
Organisme : Science and Technology Department of Zhejiang Province
ID : LGF20H060013
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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