Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration.
1H-pyrazolo[2,3-b]pyridine
Kinase inhibition
Liver failure
MKK4
NAFLD
Scaffold hopping
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Jun 2021
05 Jun 2021
Historique:
received:
22
10
2020
revised:
23
02
2021
accepted:
04
03
2021
pubmed:
2
4
2021
medline:
7
8
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
Currently, the therapeutic options for treatment of liver failure are very limited. As mitogen-activated protein kinase kinase 4 (MKK4) has recently been identified by in vivo RNAi experiments to be a major regulator in hepatocyte regeneration, we pursued the development of a small molecule targeting this protein kinase. Starting from the approved BRAF
Identifiants
pubmed: 33794385
pii: S0223-5234(21)00220-8
doi: 10.1016/j.ejmech.2021.113371
pii:
doi:
Substances chimiques
1H-pyrazolo(3,4-b)pyridine
0
Protein Kinase Inhibitors
0
Pyrazoles
0
Pyridines
0
MAP Kinase Kinase 4
EC 2.7.12.2
MAP2K4 protein, human
EC 2.7.12.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113371Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.