A Role for Vasoactive Intestinal Peptide Interneurons in Neurodevelopmental Disorders.
Autism
Epilepsy
Interneurons
Vasoactive intestinal peptide
Journal
Developmental neuroscience
ISSN: 1421-9859
Titre abrégé: Dev Neurosci
Pays: Switzerland
ID NLM: 7809375
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
12
2020
accepted:
10
02
2021
pubmed:
2
4
2021
medline:
28
1
2022
entrez:
1
4
2021
Statut:
ppublish
Résumé
GABAergic inhibitory interneurons of the cerebral cortex expressing vasoactive intestinal peptide (VIP-INs) are rapidly emerging as important regulators of network dynamics and normal circuit development. Several recent studies have also identified VIP-IN dysfunction in models of genetically determined neurodevelopmental disorders (NDDs). In this article, we review the known circuit functions of VIP-INs and how they may relate to accumulating evidence implicating VIP-INs in the mechanisms of prominent NDDs. We highlight recurring VIP-IN-mediated circuit motifs that are shared across cerebral cortical areas and how VIP-IN activity can shape sensory input, development, and behavior. Ultimately, we extract a set of themes that inform our understanding of how VIP-INs influence pathogenesis of NDDs. Using publicly available single-cell RNA sequencing data from the Allen Institute, we also identify several underexplored disease-associated genes that are highly expressed in VIP-INs. We survey these genes and their shared related disease phenotypes that may broadly implicate VIP-INs in autism spectrum disorder and intellectual disability rather than epileptic encephalopathy. Finally, we conclude with a discussion of the relevance of cell type-specific investigations and therapeutics in the age of genomic diagnosis and targeted therapeutics.
Identifiants
pubmed: 33794534
pii: 000515264
doi: 10.1159/000515264
pmc: PMC8440337
mid: NIHMS1676689
doi:
Substances chimiques
Vasoactive Intestinal Peptide
37221-79-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-180Subventions
Organisme : NINDS NIH HHS
ID : F31 NS111803
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS097633
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110869
Pays : United States
Informations de copyright
© 2021 S. Karger AG, Basel.
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