Dietary intake of vitamin A, lung function and incident asthma in childhood.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
03
12
2020
accepted:
18
03
2021
pubmed:
3
4
2021
medline:
12
11
2021
entrez:
2
4
2021
Statut:
epublish
Résumé
Longitudinal epidemiological data are scarce on the relationship between dietary intake of vitamin A and respiratory outcomes in childhood. We investigated whether a higher intake of preformed vitamin A or pro-vitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence. In the Avon Longitudinal Study of Parents and Children, dietary intakes of preformed vitamin A and β-carotene equivalents were estimated by food frequency questionnaire at 7 years of age. Post-bronchodilator forced expiratory volume in 1 s (FEV In multivariable adjusted models, a higher intake of preformed vitamin A was associated with higher lung function and a lower risk of incident asthma: comparing top A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.
Sections du résumé
BACKGROUND
Longitudinal epidemiological data are scarce on the relationship between dietary intake of vitamin A and respiratory outcomes in childhood. We investigated whether a higher intake of preformed vitamin A or pro-vitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence.
METHODS
In the Avon Longitudinal Study of Parents and Children, dietary intakes of preformed vitamin A and β-carotene equivalents were estimated by food frequency questionnaire at 7 years of age. Post-bronchodilator forced expiratory volume in 1 s (FEV
RESULTS
In multivariable adjusted models, a higher intake of preformed vitamin A was associated with higher lung function and a lower risk of incident asthma: comparing top
CONCLUSION
A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.
Identifiants
pubmed: 33795317
pii: 13993003.04407-2020
doi: 10.1183/13993003.04407-2020
pmc: PMC8551559
pii:
doi:
Substances chimiques
Vitamin A
11103-57-4
BCO1 protein, human
EC 1.14.99.36
beta-Carotene 15,15'-Monooxygenase
EC 1.14.99.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P30 ES006694
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright ©The authors 2021.
Déclaration de conflit d'intérêts
Conflict of interest: M. Talaei has nothing to disclose. Conflict of interest: D.A. Hughes has nothing to disclose. Conflict of interest: O. Mahmoud has nothing to disclose. Conflict of interest: P.M. Emmett reports grants from Nestle Nutrition, personal fees for consultancy from the European Food Safety Authority, outside the submitted work. Conflict of interest: R. Granell has nothing to disclose. Conflict of interest: S. Guerra has nothing to disclose. Conflict of interest: S.O. Shaheen has nothing to disclose.
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