Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: a GWAS meta-analysis.
Algorithms
Alleles
Attention Deficit Disorder with Hyperactivity
/ genetics
Depressive Disorder, Major
/ genetics
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genomics
Humans
Linkage Disequilibrium
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
30
06
2020
accepted:
19
03
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Attention deficit/hyperactivity disorder (ADHD) demonstrates a high level of comorbidity with major depressive disorder (MDD). One possible contributor to this is that the two disorders show high genetic correlation. However, the specific regions of the genome that may be responsible for this overlap are unclear. To identify variants associated with both ADHD and MDD, we performed a meta-analysis of GWAS of ADHD and MDD. All genome wide significant (p < 5 × 10
Identifiants
pubmed: 33795730
doi: 10.1038/s41598-021-86802-1
pii: 10.1038/s41598-021-86802-1
pmc: PMC8016853
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7353Subventions
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Références
J Affect Disord. 1994 Aug;31(4):281-94
pubmed: 7989643
Elife. 2019 Mar 21;8:
pubmed: 30895923
Nat Neurosci. 2019 Mar;22(3):353-361
pubmed: 30692689
Nat Rev Genet. 2019 Oct;20(10):567-581
pubmed: 31171865
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Am J Med Genet B Neuropsychiatr Genet. 2016 Oct;171(7):931-7
pubmed: 26710920
Twin Res. 2001 Dec;4(6):453-8
pubmed: 11780937
Clin Psychol Rev. 2014 Dec;34(8):595-607
pubmed: 25455624
JAMA Psychiatry. 2019 Mar 1;76(3):306-313
pubmed: 30326013
Nat Rev Genet. 2013 Jun;14(6):379-89
pubmed: 23657481
Am J Psychiatry. 2009 Sep;166(9):1048-54
pubmed: 19570932
Eur J Med Genet. 2009 Jul-Aug;52(4):265-8
pubmed: 19100872
J Affect Disord. 2018 Feb;227:56-64
pubmed: 29053976
Arch Gen Psychiatry. 2011 Feb;68(2):181-9
pubmed: 21300945
Cell. 2019 Dec 12;179(7):1469-1482.e11
pubmed: 31835028
J Abnorm Psychol. 2010 Nov;119(4):699-712
pubmed: 20853914
J Am Acad Child Adolesc Psychiatry. 2009 Nov;48(11):1094-1101
pubmed: 19797986
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Nat Genet. 2018 May;50(5):668-681
pubmed: 29700475
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Lancet. 2012 Mar 17;379(9820):1056-67
pubmed: 22305766
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
J Affect Disord. 2017 Jun;215:281-287
pubmed: 28363151
Am J Med Genet A. 2006 Jan 15;140(2):186-8
pubmed: 16353254
PLoS One. 2013;8(1):e54276
pubmed: 23342115
JAMA Psychiatry. 2017 Feb 1;74(2):153-160
pubmed: 27926743
Nat Neurosci. 2004 Nov;7(11):1213-21
pubmed: 15494734
Am J Med Genet B Neuropsychiatr Genet. 2017 Jul;174(5):538-546
pubmed: 28436115
BMJ. 2001 Jan 27;322(7280):226-31
pubmed: 11159626
J Am Acad Child Adolesc Psychiatry. 2008 Apr;47(4):426-434
pubmed: 18388760
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
Arch Gen Psychiatry. 2010 Oct;67(10):1044-51
pubmed: 20921120
Mol Psychiatry. 2020 Aug;25(8):1809-1821
pubmed: 29934545
Lancet. 2016 Mar 19;387(10024):1240-50
pubmed: 26386541
Am J Hum Genet. 2017 Nov 2;101(5):737-751
pubmed: 29100087
Neuron. 2014 Feb 5;81(3):484-503
pubmed: 24507187
Nat Genet. 2017 Apr;49(4):606-612
pubmed: 28250456
Am J Psychiatry. 2018 Oct 1;175(10):943-950
pubmed: 30111187
Eur Neuropsychopharmacol. 2016 Nov;26(11):1760-1767
pubmed: 27667705
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):635-643
pubmed: 30047479