(±)-
Alzheimer’s disease
Biginelli reaction
GSK 3β
MAO
calcium channel
cholinesterases
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
21 04 2021
21 04 2021
Historique:
pubmed:
3
4
2021
medline:
22
6
2021
entrez:
2
4
2021
Statut:
ppublish
Résumé
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)
Identifiants
pubmed: 33797877
doi: 10.1021/acschemneuro.0c00803
doi:
Substances chimiques
Calcium Channel Blockers
0
Calcium Channels
0
Cholinesterase Inhibitors
0
Ligands
0
Monoamine Oxidase
EC 1.4.3.4
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM