COR758, a negative allosteric modulator of GABA

Allosteric Regulation / drug effects Animals Bioluminescence Resonance Energy Transfer Techniques / methods CHO Cells Cricetulus Dose-Response Relationship, Drug GABA Modulators / chemistry GABA-B Receptor Agonists / chemistry GABA-B Receptor Antagonists / chemistry Humans Male Rats Rats, Sprague-Dawley Receptors, GABA-B / physiology gamma-Aminobutyric Acid / chemistry
Allosteric modulators Bioluminescence resonance energy transfer (BRET) GABA(B) receptors GTPγS binding Negative allosteric modulator (NAM)

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
15 05 2021
Historique:
received: 03 09 2020
revised: 20 03 2021
accepted: 22 03 2021
pubmed: 3 4 2021
medline: 15 12 2021
entrez: 2 4 2021
Statut: ppublish

Résumé

Allosteric modulators of G protein coupled receptors (GPCRs), including GABA

Identifiants

DOI: 10.1016/j.neuropharm.2021.108537 PMID: 33798546
pubmed: 33798546
pii: S0028-3908(21)00091-5
doi: 10.1016/j.neuropharm.2021.108537
pii:
doi:

Substances chimiques

GABA Modulators 0
GABA-B Receptor Agonists 0
GABA-B Receptor Antagonists 0
Receptors, GABA-B 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108537

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Alessandra Porcu (A)

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy; Department of Biomedicine, University of Basel, Klingelbergstrasse 50-70, CH-4056, Basel, Switzerland.

Rafaela Mostallino (R)

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy.

Valeria Serra (V)

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy.

Miriam Melis (M)

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy.

Valeria Sogos (V)

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy.

Sarah Beggiato (S)

Department of Life Sciences and Biotechnology, Section of Medicinal and Health Products, and LTTA Center, University of Ferrara, Ferrara, Italy; Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100, Chieti, Italy.

Luca Ferraro (L)

Department of Life Sciences and Biotechnology, Section of Medicinal and Health Products, and LTTA Center, University of Ferrara, Ferrara, Italy.

Fabrizio Manetti (F)

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100, Siena, SI, Italy.

Beatrice Gianibbi (B)

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100, Siena, SI, Italy.

Bernhard Bettler (B)

Department of Biomedicine, University of Basel, Klingelbergstrasse 50-70, CH-4056, Basel, Switzerland.

Federico Corelli (F)

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100, Siena, SI, Italy.

Claudia Mugnaini (C)

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100, Siena, SI, Italy.

M Paola Castelli (MP)

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy; Guy Everett Laboratory, University of Cagliari, 09042, Monserrato, Italy; Center of Excellence "Neurobiology of Addiction", University of Cagliari, 09042, Monserrato, Italy. Electronic address: castelli@unica.it.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Eucaryotes › Animaux › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Photométrie › Mesures de luminescence › Techniques de transfert d'énergie par résonance de bioluminescence › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Modulateurs GABA › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Agonistes GABA › Agonistes du recepteur GABA-B › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Antagonistes GABA › Antagonistes du récepteur GABA-B › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-B › COR758, a negative allosteric modulator of GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › COR758, a negative allosteric modulator of GABA