Postbiotics, Metabolic Signaling, and Cancer.
Butyrates
/ pharmacology
Dietary Supplements
/ microbiology
Fatty Acids, Volatile
/ metabolism
Gastrointestinal Microbiome
/ drug effects
Humans
Hydrogen Sulfide
/ pharmacology
Lactic Acid
/ pharmacology
Metabolome
Neoplasms
/ diet therapy
Prebiotics
/ microbiology
Probiotics
/ metabolism
beta-Glucans
/ pharmacology
GPR81
SCFA
colorectal cancer
functional food
intestinal metabolome
microbiome
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
09
02
2021
revised:
05
03
2021
accepted:
09
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Postbiotics are health-promoting microbial metabolites delivered as a functional food or a food supplement. They either directly influence signaling pathways of the body or indirectly manipulate metabolism and the composition of intestinal microflora. Cancer is the second leading cause of death worldwide and even though the prognosis of patients is improving, it is still poor in the substantial part of the cases. The preventable nature of cancer and the importance of a complex multi-level approach in anticancer therapy motivate the search for novel avenues of establishing the anticancer environment in the human body. This review summarizes the principal findings demonstrating the usefulness of both natural and synthetic sources of postbotics in the prevention and therapy of cancer. Specifically, the effects of crude cell-free supernatants, the short-chain fatty acid butyrate, lactic acid, hydrogen sulfide, and β-glucans are described. Contradictory roles of postbiotics in healthy and tumor tissues are highlighted. In conclusion, the application of postbiotics is an efficient complementary strategy to combat cancer.
Identifiants
pubmed: 33799580
pii: molecules26061528
doi: 10.3390/molecules26061528
pmc: PMC8000401
pii:
doi:
Substances chimiques
Butyrates
0
Fatty Acids, Volatile
0
Prebiotics
0
beta-Glucans
0
Lactic Acid
33X04XA5AT
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grantová Agentura České Republiky
ID : 21-11688S
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