Effects of a Novel GPR55 Antagonist on the Arachidonic Acid Cascade in LPS-Activated Primary Microglial Cells.
Animals
Anti-Inflammatory Agents
/ chemistry
Arachidonic Acid
/ metabolism
Cyclooxygenase 2
/ metabolism
Dinoprostone
/ metabolism
Inflammation
/ drug therapy
Lipopolysaccharides
/ pharmacology
Microglia
/ drug effects
NF-kappa B
/ metabolism
Rats
Rats, Sprague-Dawley
Receptors, Cannabinoid
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Signal Transduction
GPR55
cyclooxygenase
microglia
neuroinflammation
prostaglandin E2
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Mar 2021
02 Mar 2021
Historique:
received:
14
01
2021
revised:
24
02
2021
accepted:
25
02
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
13
5
2021
Statut:
epublish
Résumé
Neuroinflammation is a crucial process to maintain homeostasis in the central nervous system (CNS). However, chronic neuroinflammation is detrimental, and it is described in the pathogenesis of CNS disorders, including Alzheimer's disease (AD) and depression. This process is characterized by the activation of immune cells, mainly microglia. The role of the orphan G-protein-coupled receptor 55 (GPR55) in inflammation has been reported in different models. However, its role in neuroinflammation in respect to the arachidonic acid (AA) cascade in activated microglia is still lacking of comprehension. Therefore, we synthesized a novel GPR55 antagonist (
Identifiants
pubmed: 33801492
pii: ijms22052503
doi: 10.3390/ijms22052503
pmc: PMC7958845
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
GPR55 protein, rat
0
Lipopolysaccharides
0
NF-kappa B
0
Receptors, Cannabinoid
0
Receptors, G-Protein-Coupled
0
Arachidonic Acid
27YG812J1I
Cyclooxygenase 2
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Dig Dis Sci. 2005 Oct;50 Suppl 1:S16-23
pubmed: 16184416
Bioorg Med Chem. 2009 Apr 1;17(7):2842-51
pubmed: 19278853
J Neurosci Res. 1997 Aug 1;49(3):292-300
pubmed: 9260740
J Neuroinflammation. 2016 Jun 14;13(1):148
pubmed: 27301644
Biochem Biophys Res Commun. 2007 Nov 3;362(4):928-34
pubmed: 17765871
Glia. 2013 Nov;61(11):1822-31
pubmed: 24038453
Neurochem Res. 2005 Jun-Jul;30(6-7):883-93
pubmed: 16187223
Chem Biol Interact. 2020 Jul 1;325:109088
pubmed: 32360554
J Biochem Mol Biol. 2005 Nov 30;38(6):633-8
pubmed: 16336776
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034
pubmed: 20066092
Neuropathol Appl Neurobiol. 2013 Feb;39(1):3-18
pubmed: 23252647
Mol Cancer. 2013 Aug 02;12:86
pubmed: 23915189
Int J Cancer. 2018 Jan 1;142(1):121-132
pubmed: 28875496
Annu Rev Biochem. 1975;44:669-95
pubmed: 806254
J Med Chem. 2013 Jun 13;56(11):4798-810
pubmed: 23679955
J Gastroenterol Hepatol. 2014 Dec;29 Suppl 4:3-10
pubmed: 25521725
Biochim Biophys Acta. 2005 Dec 30;1754(1-2):253-62
pubmed: 16198162
Brain Behav Immun. 2019 Feb;76:165-181
pubmed: 30465881
J Neuroinflammation. 2018 Nov 19;15(1):322
pubmed: 30453998
Trends Pharmacol Sci. 2018 Jun;39(6):586-604
pubmed: 29588059
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16511-6
pubmed: 19805329
Inflammation. 2020 Oct;43(5):1971-1987
pubmed: 32519268
Annu Rev Immunol. 2009;27:119-45
pubmed: 19302036
Int Immunol. 2015 Mar;27(3):153-60
pubmed: 25344934
J Med Chem. 2012 Sep 27;55(18):7967-77
pubmed: 22916707
J Neuroinflammation. 2017 Dec 13;14(1):246
pubmed: 29237478
PLoS One. 2015 Sep 17;10(9):e0138710
pubmed: 26379052
Trends Pharmacol Sci. 2009 Mar;30(3):156-63
pubmed: 19233486
Curr Neuropharmacol. 2017;15(5):771-778
pubmed: 27488130
Br J Pharmacol. 2010 Jun;160(3):604-14
pubmed: 20136841
J Biol Chem. 2009 Oct 23;284(43):29817-27
pubmed: 19723626
Sci Rep. 2017 Dec;7(1):116
pubmed: 28273917
Glia. 2005 Aug 15;51(3):199-208
pubmed: 15800925
Nat Rev Neurol. 2010 Apr;6(4):193-201
pubmed: 20234358
J Neurochem. 1995 Dec;65(6):2690-8
pubmed: 7595567
Front Pharmacol. 2016 Aug 22;7:264
pubmed: 27597829
Evid Based Complement Alternat Med. 2013;2013:459723
pubmed: 23737832
Glia. 2008 Jun;56(8):844-55
pubmed: 18383341
Pain. 2008 Sep 30;139(1):225-236
pubmed: 18502582
FEBS Lett. 2009 Jun 18;583(12):2071-6
pubmed: 19464294
Am J Physiol. 1991 Feb;260(2 Pt 1):L13-28
pubmed: 1899973
Immunology. 2018 Jun;154(2):204-219
pubmed: 29513402
J Biochem. 2010 May;147(5):671-8
pubmed: 20051382
Neurogastroenterol Motil. 2015 Oct;27(10):1432-45
pubmed: 26227635
J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):297-302
pubmed: 26669245
Eur J Biochem. 1997 Feb 1;243(3):726-31
pubmed: 9057838
Mol Neurobiol. 2017 Dec;54(10):8071-8089
pubmed: 27889895
Neuron. 2002 Aug 1;35(3):419-32
pubmed: 12165466
J Pharmacol Exp Ther. 2013 Jul;346(1):54-66
pubmed: 23639801