Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy).
antioxidants
neuroprotection
neurotrophins
olive oil
oxidative stress
phenols
proteomics
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
10 Mar 2021
10 Mar 2021
Historique:
received:
11
02
2021
revised:
02
03
2021
accepted:
05
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Neurodegenerative diseases are driven by several mechanisms such as inflammation, abnormal protein aggregation, excitotoxicity, mitochondrial dysfunction and oxidative stress. So far, no therapeutic strategies are available for neurodegenerative diseases and in recent years the research is focusing on bioactive molecules present in food. In particular, extra-virgin olive oil (EVOO) phenols have been associated to neuroprotection. In this study, we investigated the potential antioxidant and neuroprotective activity of two different EVOO extracts obtained from Quercetano cultivar trees grown in two different areas (plain and hill) of the Tuscany region (Italy). The different geographical origin of the orchards influenced phenol composition. Plain extract presented a higher content of phenyl ethyl alcohols, cinnammic acids, oleacein, oleocanthal and flavones; meanwhile, hill extract was richer in lignans. Hill extract was more effective in protecting differentiated SH-SY5Y cells from peroxide stress thanks to a marked upregulation of the antioxidant enzymes heme oxygenase 1, NADPH quinone oxidoreductase 1, thioredoxin Reductase 1 and glutathione reductase. Proteomic analysis revealed that hill extract plays a role in the regulation of proteins involved in neuronal plasticity and activation of neurotrophic factors such as BDNF. In conclusion, these data demonstrate that EVOOs can have important neuroprotective activities, but these effects are strictly related to their specific phenol composition.
Identifiants
pubmed: 33801925
pii: antiox10030421
doi: 10.3390/antiox10030421
pmc: PMC8000409
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 20152HKF3Z
Organisme : University of Bologna
ID : RFO2019
Références
Chem Res Toxicol. 2015 Jun 15;28(6):1234-45
pubmed: 25933243
J Nutr. 2005 Jun;135(6):1475-9
pubmed: 15930455
Plant Cell Environ. 2009 Mar;32(3):286-99
pubmed: 19054348
J Sep Sci. 2005 Jun;28(9-10):837-58
pubmed: 16013811
Int J Mol Sci. 2020 Oct 21;21(20):
pubmed: 33096634
Brain Res Mol Brain Res. 2000 Mar 29;76(2):347-54
pubmed: 10762711
Oxid Med Cell Longev. 2020 Aug 1;2020:8363245
pubmed: 32832006
Redox Biol. 2015 Dec;6:183-197
pubmed: 26233704
N Engl J Med. 1994 Mar 3;330(9):613-22
pubmed: 7905600
Molecules. 2016 Dec 16;21(12):
pubmed: 27999296
Mol Neurobiol. 2020 Jan;57(1):261-277
pubmed: 31317491
Phytomedicine. 2019 Feb;53:143-153
pubmed: 30668393
Antioxidants (Basel). 2020 Jul 28;9(8):
pubmed: 32731644
J Chromatogr A. 2017 Jan 20;1481:53-63
pubmed: 28024731
Toxicol In Vitro. 2018 Oct;52:243-250
pubmed: 29959992
Nutrients. 2019 Mar 31;11(4):
pubmed: 30935111
Sci Rep. 2018 Feb 9;8(1):2722
pubmed: 29426875
J Sci Food Agric. 2017 Aug;97(11):3530-3539
pubmed: 28071794
Toxicol Appl Pharmacol. 2010 Apr 1;244(1):57-65
pubmed: 20122946
Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):14-8
pubmed: 19834324
Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
pubmed: 9240432
J Nutr Biochem. 2017 Apr;42:26-36
pubmed: 28110122
Neurobiol Dis. 2008 Sep;31(3):316-26
pubmed: 18585459
Biochim Biophys Acta. 2014 Sep;1842(9):1693-706
pubmed: 24949886
Food Chem Toxicol. 2019 Mar;125:376-382
pubmed: 30685474
Arch Pharm Res. 2015 Jan;38(1):26-34
pubmed: 24676553
Sci Rep. 2017 Oct 18;7(1):13445
pubmed: 29044173
Exp Neurol. 2020 Jun;328:113248
pubmed: 32084452
Public Health Nutr. 2011 Dec;14(12A):2274-84
pubmed: 22166184
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
J Mol Neurosci. 2020 Aug;70(8):1293-1302
pubmed: 32458204
Crit Rev Food Sci Nutr. 2009 Mar;49(3):218-36
pubmed: 19093267
Nutr Res Rev. 2005 Jun;18(1):98-112
pubmed: 19079898
Expert Rev Neurother. 2017 Apr;17(4):345-358
pubmed: 27762153
Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):51-62
pubmed: 25405316
Int J Mol Sci. 2020 Feb 10;21(3):
pubmed: 32050617
Molecules. 2007 Aug 06;12(8):1679-719
pubmed: 17960082
Antioxidants (Basel). 2014 May 13;3(2):387-413
pubmed: 26784878
Brain Res Brain Res Rev. 2000 Sep;33(2-3):199-227
pubmed: 11011066
Lancet. 2018 Sep 22;392(10152):1072-1088
pubmed: 30264707
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14960-5
pubmed: 8962164
Int J Mol Sci. 2018 Aug 08;19(8):
pubmed: 30096819
Neurotoxicology. 2009 Jan;30(1):127-35
pubmed: 19056420
Sci Rep. 2017 Sep 4;7(1):10378
pubmed: 28871128
J Biomol Struct Dyn. 2021 Mar;39(4):1259-1270
pubmed: 32041489
J Oleo Sci. 2017 Aug 1;66(8):907-915
pubmed: 28701656
Eur J Neurosci. 2005 Sep;22(5):1081-9
pubmed: 16176349
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3270-4
pubmed: 8159737
Neuropharmacology. 2012 Feb;62(2):997-1003
pubmed: 22032870
Mol Biosyst. 2015 Jun;11(6):1696-707
pubmed: 25912719
Nat Rev Neurosci. 2001 Jan;2(1):24-32
pubmed: 11253356
Ann Neurol. 2006 Jun;59(6):912-21
pubmed: 16622828
Neural Regen Res. 2017 Apr;12(4):549-557
pubmed: 28553325
Eur J Med Chem. 2019 May 1;169:185-199
pubmed: 30877973
Int J Mol Sci. 2017 Oct 25;18(11):
pubmed: 29068387
Biochem Biophys Res Commun. 2005 Feb 25;327(4):1058-65
pubmed: 15652504
Neurobiol Dis. 2006 May;22(2):302-11
pubmed: 16442805
Curr Opin Neurobiol. 2001 Jun;11(3):272-80
pubmed: 11399424
Exp Neurol. 2014 Jul;257:130-47
pubmed: 24792640
Cell Metab. 2013 Dec 3;18(6):844-59
pubmed: 24315370
ASN Neuro. 2020 Jan-Dec;12:1759091419899782
pubmed: 31964153
Biochim Biophys Acta. 2014 Aug;1842(8):1240-7
pubmed: 24189435
Food Chem. 2012 Dec 15;135(4):2561-8
pubmed: 22980843
J Neural Transm Suppl. 2002;(62):241-52
pubmed: 12456067
Tree Physiol. 2004 Nov;24(11):1303-11
pubmed: 15339740
Cancer Res. 2006 Apr 15;66(8):4240-8
pubmed: 16618747
Biochem Pharmacol. 1998 Sep 1;56(5):645-55
pubmed: 9783733
Toxicol Ind Health. 2009 May-Jun;25(4-5):285-93
pubmed: 19651799
Oxid Med Cell Longev. 2017;2017:2525967
pubmed: 28785371
Mol Nutr Food Res. 2010 Apr;54(4):532-42
pubmed: 20166144
Free Radic Biol Med. 2015 Nov;88(Pt B):179-188
pubmed: 25975984
Oxid Med Cell Longev. 2013;2013:415078
pubmed: 23983898
Eur J Med Chem. 2017 Oct 20;139:378-389
pubmed: 28810189
Plant Mol Biol. 1998 May;37(2):217-23
pubmed: 9617795
Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):148-54
pubmed: 12654514
Foods. 2020 Jul 09;9(7):
pubmed: 32660116
J Neural Transm Suppl. 2007;(72):17-28
pubmed: 17982873
Antioxidants (Basel). 2020 Apr 17;9(4):
pubmed: 32316684
Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):385-94
pubmed: 15706085
Food Res Int. 2020 Jul;133:109128
pubmed: 32466943
J Transl Med. 2013 Oct 02;11:243
pubmed: 24088505
Mol Neurobiol. 2021 May;58(5):2158-2182
pubmed: 33411248
Int J Mol Sci. 2017 May 31;18(6):
pubmed: 28561773
Planta. 2012 Oct;236(4):1067-80
pubmed: 22569920
Brain Res Bull. 2018 Jun;140:65-71
pubmed: 29626606
Trends Neurosci. 2000 Jul;23(7):298-304
pubmed: 10856939
Neuron. 1991 Nov;7(5):695-702
pubmed: 1742020
Arch Neurol. 2006 Dec;63(12):1709-17
pubmed: 17030648
Stem Cell Res Ther. 2020 Apr 16;11(1):155
pubmed: 32299503
J Alzheimers Dis. 2015;45(3):679-88
pubmed: 25649656
Recent Pat CNS Drug Discov. 2012 Dec;7(3):218-29
pubmed: 22742419
Cell Mol Neurobiol. 2017 May;37(4):665-682
pubmed: 27422411