Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy.
immunotherapy
influenza
nanobodies
single domain antibodies
vaccine potency testing
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
10 03 2021
10 03 2021
Historique:
received:
27
01
2021
revised:
05
03
2021
accepted:
06
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
15
9
2021
Statut:
epublish
Résumé
The antigenic variability of influenza presents many challenges to the development of vaccines and immunotherapeutics. However, it is apparent that there are epitopes on the virus that have evolved to remain largely constant due to their functional importance. These more conserved regions are often hidden and difficult to access by the human immune system but recent efforts have shown that these may be the Achilles heel of the virus through development and delivery of appropriate biological drugs. Amongst these, single domain antibodies (sdAbs) are equipped to target these vulnerabilities of the influenza virus due to their preference for concave epitopes on protein surfaces, their small size, flexible reformatting and high stability. Single domain antibodies are well placed to provide a new generation of robust analytical reagents and therapeutics to support the constant efforts to keep influenza in check.
Identifiants
pubmed: 33802072
pii: biom11030407
doi: 10.3390/biom11030407
pmc: PMC8001348
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Influenza Vaccines
0
Single-Domain Antibodies
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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