Intratumor Regulatory Noncytotoxic NK Cells in Patients with Hepatocellular Carcinoma.
hepatocellular carcinoma
natural killer cells
tumor microenvironment
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
10 03 2021
10 03 2021
Historique:
received:
03
10
2020
revised:
05
03
2021
accepted:
07
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Previous studies support the role of natural killer (NK) cells in controlling hepatocellular carcinoma (HCC) progression. However, ambiguity remains about the multiplicity and the role of different NK cell subsets, as a pro-oncogenic function has been suggested. We performed phenotypic and functional characterization of NK cells infiltrating HCC, with the corresponding nontumorous tissue and liver from patients undergoing liver resection for colorectal liver metastasis used as controls. We identified a reduced number of NK cells in tumors with higher frequency of CD56
Identifiants
pubmed: 33802077
pii: cells10030614
doi: 10.3390/cells10030614
pmc: PMC7999652
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 15485
Organisme : Accelerator Award (AIRC, CRUK, AECC)
ID : 22794
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