Assessing Plasmin Generation in Health and Disease.
fibrinolysis
plasmin
plasmin generation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Mar 2021
09 Mar 2021
Historique:
received:
01
02
2021
revised:
20
02
2021
accepted:
05
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
21
4
2021
Statut:
epublish
Résumé
Fibrinolysis is an important process in hemostasis responsible for dissolving the clot during wound healing. Plasmin is a central enzyme in this process via its capacity to cleave fibrin. The kinetics of plasmin generation (PG) and inhibition during fibrinolysis have been poorly understood until the recent development of assays to quantify these metrics. The assessment of plasmin kinetics allows for the identification of fibrinolytic dysfunction and better understanding of the relationships between abnormal fibrin dissolution and disease pathogenesis. Additionally, direct measurement of the inhibition of PG by antifibrinolytic medications, such as tranexamic acid, can be a useful tool to assess the risks and effectiveness of antifibrinolytic therapy in hemorrhagic diseases. This review provides an overview of available PG assays to directly measure the kinetics of plasmin formation and inhibition in human and mouse plasmas and focuses on their applications in defining the role of plasmin in diseases, including angioedema, hemophilia, rare bleeding disorders, COVID-19, or diet-induced obesity. Moreover, this review introduces the PG assay as a promising clinical and research method to monitor antifibrinolytic medications and screen for genetic or acquired fibrinolytic disorders.
Identifiants
pubmed: 33803235
pii: ijms22052758
doi: 10.3390/ijms22052758
pmc: PMC7963172
pii:
doi:
Substances chimiques
Antifibrinolytic Agents
0
Fibrinolytic Agents
0
Fibrin
9001-31-4
Plasminogen
9001-91-6
Fibrinolysin
EC 3.4.21.7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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