The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?
Aging
/ metabolism
Angiotensin Receptor Antagonists
/ pharmacology
Angiotensin-Converting Enzyme Inhibitors
/ pharmacology
Animals
Autoimmunity
/ drug effects
COVID-19
/ genetics
Cardiovascular Diseases
/ genetics
Humans
Inflammation
/ drug therapy
Peptidyl-Dipeptidase A
/ metabolism
Receptors, Angiotensin
/ genetics
Regeneration
/ drug effects
Renin-Angiotensin System
/ drug effects
Vulvodynia
/ immunology
COVID-19 Drug Treatment
COVID-19
RAS
cardiovascular
inflammation
intervertebral disc
regeneration
renin-angiotensin
senescence
vulvodynia
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
25
01
2021
revised:
09
03
2021
accepted:
13
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
23
4
2021
Statut:
epublish
Résumé
Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the Angiotensin Converting Enzyme (ACE)/Angiotensin II (AngII)/Angiotensin II receptor type 1 (AGTR1) axis and a protective anti-inflammatory pathway involving the Angiotensin II receptor type 2 (AGTR2)/ACE2/Ang1-7/MasReceptor axis. Numerous studies reported the positive effects of pathologic tRAS pathway inhibition and protective tRAS pathway stimulation on the treatment of cardiovascular, inflammatory, and autoimmune disease and the progression of neuropathic pain. Cell senescence and aging are known to be related to RAS pathways. Further, this system directly interacts with SARS-CoV 2 and seems to be an important target of interest in the COVID-19 pandemic. This review focuses on the involvement of tRAS in the progression of the mentioned diseases from an interdisciplinary clinical perspective and highlights therapeutic strategies that might be of major clinical importance in the future.
Identifiants
pubmed: 33804069
pii: cells10030650
doi: 10.3390/cells10030650
pmc: PMC7999456
pii:
doi:
Substances chimiques
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Receptors, Angiotensin
0
ACE protein, human
EC 3.4.15.1
Peptidyl-Dipeptidase A
EC 3.4.15.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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