The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials.
non-alcoholic fatty liver disease
nutraceutical
oxidative stress
resveratrol
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
13 Mar 2021
13 Mar 2021
Historique:
received:
16
02
2021
revised:
10
03
2021
accepted:
11
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection.
Identifiants
pubmed: 33805795
pii: nu13030933
doi: 10.3390/nu13030933
pmc: PMC7999728
pii:
doi:
Substances chimiques
Antioxidants
0
Resveratrol
Q369O8926L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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