Potential of Nutraceutical Supplementation in the Modulation of White and Brown Fat Tissues in Obesity-Associated Disorders: Role of Inflammatory Signalling.
Adipogenesis
Adipose Tissue
/ metabolism
Adipose Tissue, Brown
/ metabolism
Adipose Tissue, White
/ metabolism
Animals
Curcumin
/ chemistry
Diet
Dietary Supplements
Endoplasmic Reticulum
/ metabolism
Fatty Acids, Unsaturated
/ metabolism
Humans
Inflammation
/ metabolism
Insulin Resistance
Intestines
/ chemistry
Lipids
/ chemistry
Macrophages
/ metabolism
Obesity
/ metabolism
Polyphenols
/ chemistry
Resveratrol
/ pharmacology
Signal Transduction
Thermogenesis
BAT
WAT
browning
inflammation
metabolic diseases
nutraceutical supplementation
obesity
polyphenols
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Mar 2021
25 Mar 2021
Historique:
received:
17
02
2021
revised:
20
03
2021
accepted:
22
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
17
6
2021
Statut:
epublish
Résumé
The high incidence of obesity is associated with an increasing risk of several chronic diseases such as cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Sustained obesity is characterized by a chronic and unsolved inflammation of adipose tissue, which leads to a greater expression of proinflammatory adipokines, excessive lipid storage and adipogenesis. The purpose of this review is to clarify how inflammatory mediators act during adipose tissue dysfunction in the development of insulin resistance and all obesity-associated diseases. In particular, we focused our attention on the role of inflammatory signaling in brown adipose tissue (BAT) thermogenic activity and the browning of white adipose tissue (WAT), which represent a relevant component of adipose alterations during obesity. Furthermore, we reported the most recent evidence in the literature on nutraceutical supplementation in the management of the adipose inflammatory state, and in particular on their potential effect on common inflammatory mediators and pathways, responsible for WAT and BAT dysfunction. Although further research is needed to demonstrate that targeting pro-inflammatory mediators improves adipose tissue dysfunction and activates thermogenesis in BAT and WAT browning during obesity, polyphenols supplementation could represent an innovative therapeutic strategy to prevent progression of obesity and obesity-related metabolic diseases.
Identifiants
pubmed: 33805912
pii: ijms22073351
doi: 10.3390/ijms22073351
pmc: PMC8037903
pii:
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Lipids
0
Polyphenols
0
Curcumin
IT942ZTH98
Resveratrol
Q369O8926L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : PONMIUR; POR
ID : PON-MIUR 03PE000_78_1 and PONMIUR 03PE000_78_2. POR Calabria FESR FSE 2014-2020 Asse 12-Azioni 10.5.6 e 10.5.12. POR Calabria FESR FSE 2014-2020 azione 1.5.1: progetto AgrInfra Calabria
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