More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases.
cancer
cataract
cells development
cellular stress
heat shock factors
transcription regulation
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
31 03 2021
31 03 2021
Historique:
received:
08
03
2021
revised:
27
03
2021
accepted:
29
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Cells encounter a myriad of endogenous and exogenous stresses that could perturb cellular physiological processes. Therefore, cells are equipped with several adaptive and stress-response machinery to overcome and survive these insults. One such machinery is the heat shock response (HSR) program that is governed by the heat shock factors (HSFs) family in response towards elevated temperature, free radicals, oxidants, and heavy metals. HSF4 is a member of this HSFs family that could exist in two predominant isoforms, either the transcriptional repressor HSFa or transcriptional activator HSF4b. HSF4 is constitutively active due to the lack of oligomerization negative regulator domain. HSF4 has been demonstrated to play roles in several physiological processes and not only limited to regulating the classical heat shock- or stress-responsive transcriptional programs. In this review, we will revisit and delineate the recent updates on HSF4 molecular properties. We also comprehensively discuss the roles of HSF4 in health and diseases, particularly in lens cell development, cataract formation, and cancer pathogenesis. Finally, we will posit the potential direction of HSF4 future research that could enhance our knowledge on HSF4 molecular networks as well as physiological and pathophysiological functions.
Identifiants
pubmed: 33807297
pii: biom11040523
doi: 10.3390/biom11040523
pmc: PMC8066111
pii:
doi:
Substances chimiques
HSF4 protein, human
0
Heat Shock Transcription Factors
0
Protein Isoforms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Universiti Kebangsaan Malaysia
ID : Geran Galakan Penyelidik Muda, GGPM-2020-035.
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