Novel Molecular Insights into Human Lipid-Mediated T Cell Immunity.
CD1 molecules
NKT cells
immunity
lipids
αβ and γδ T cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
05
02
2021
revised:
02
03
2021
accepted:
03
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
23
4
2021
Statut:
epublish
Résumé
T cells represent a critical arm of our immune defense against pathogens. Over the past two decades, considerable inroads have been made in understanding the fundamental principles underpinning the molecular presentation of peptide-based antigens by the Major Histocompatibility Complex molecules (MHC-I and II), and their molecular recognition by specialized subsets of T cells. However, some T cells can recognize lipid-based antigens presented by MHC-I-like molecules that belong to the Cluster of Differentiation 1 (CD1) family. Here, we will review the advances that have been made in the last five years to understand the molecular mechanisms orchestrating the presentation of novel endogenous and exogenous lipid-based antigens by the CD1 glycoproteins and their recognition by specific populations of CD1-reactive T cells.
Identifiants
pubmed: 33807663
pii: ijms22052617
doi: 10.3390/ijms22052617
pmc: PMC7961386
pii:
doi:
Substances chimiques
Antigens
0
Antigens, CD1
0
Histocompatibility Antigens Class I
0
Lipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Australian Research Council
ID : FT160100074
Organisme : Australian Research Council
ID : DE210101031
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