Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals.
Adult
Bacterial Translocation
Bifidobacterium
Biomarkers
/ blood
Diet, Mediterranean
Female
Gastrointestinal Microbiome
/ drug effects
HIV Infections
/ diet therapy
HIV-1
Humans
Inflammation
/ blood
Lipids
/ blood
Male
Middle Aged
Nuts
Olive Oil
Patient Compliance
Succinivibrionaceae
T-Lymphocyte Subsets
HIV-1
Treg cells
gut microbiota
lipids
lymphocyte subsets
supplemented Mediterranean diet
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Mar 2021
30 Mar 2021
Historique:
received:
23
02
2021
revised:
19
03
2021
accepted:
24
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
3
6
2021
Statut:
epublish
Résumé
The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Individuals living with HIV ( Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the
Identifiants
pubmed: 33808476
pii: nu13041141
doi: 10.3390/nu13041141
pmc: PMC8067262
pii:
doi:
Substances chimiques
Biomarkers
0
Lipids
0
Olive Oil
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : SPANISH AIDS Research Network (RIS)
ID : RD16/0025/0002 and RD16/0025/0013
Organisme : Spanish Ministry of Economy (MINECO)
ID : SAF2015-66193-R
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