The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy.
Animals
Anticonvulsants
/ pharmacology
Biomarkers
Disease Susceptibility
Epilepsy
/ diagnosis
GABA Antagonists
/ pharmacology
Humans
Isoenzymes
Receptors, GABA
/ metabolism
Signal Transduction
/ drug effects
Synapses
/ metabolism
Synaptic Transmission
Type C Phospholipases
/ metabolism
gamma-Aminobutyric Acid
/ metabolism
GABAergic inhibition
Phospholipase C (PLC)
epilepsy
excitatory/inhibitory balance (E/I balance)
γ-aminobutyric acid (GABA)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Mar 2021
19 Mar 2021
Historique:
received:
29
11
2020
revised:
02
03
2021
accepted:
17
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
29
4
2021
Statut:
epublish
Résumé
Epilepsy is characterized by recurrent seizures due to abnormal hyperexcitation of neurons. Recent studies have suggested that the imbalance of excitation and inhibition (E/I) in the central nervous system is closely implicated in the etiology of epilepsy. In the brain, GABA is a major inhibitory neurotransmitter and plays a pivotal role in maintaining E/I balance. As such, altered GABAergic inhibition can lead to severe E/I imbalance, consequently resulting in excessive and hypersynchronous neuronal activity as in epilepsy. Phospholipase C (PLC) is a key enzyme in the intracellular signaling pathway and regulates various neuronal functions including neuronal development, synaptic transmission, and plasticity in the brain. Accumulating evidence suggests that neuronal PLC is critically involved in multiple aspects of GABAergic functions. Therefore, a better understanding of mechanisms by which neuronal PLC regulates GABAergic inhibition is necessary for revealing an unrecognized linkage between PLC and epilepsy and developing more effective treatments for epilepsy. Here we review the function of PLC in GABAergic inhibition in the brain and discuss a pathophysiological relationship between PLC and epilepsy.
Identifiants
pubmed: 33808762
pii: ijms22063149
doi: 10.3390/ijms22063149
pmc: PMC8003358
pii:
doi:
Substances chimiques
Anticonvulsants
0
Biomarkers
0
GABA Antagonists
0
Isoenzymes
0
Receptors, GABA
0
gamma-Aminobutyric Acid
56-12-2
Type C Phospholipases
EC 3.1.4.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2020R1A2C1005492
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