Characterization of the Features of Water Inside the SecY Translocon.
Confined water
Membrane protein folding
Protein-conducting channel
Journal
The Journal of membrane biology
ISSN: 1432-1424
Titre abrégé: J Membr Biol
Pays: United States
ID NLM: 0211301
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
28
11
2020
accepted:
23
03
2021
pubmed:
4
4
2021
medline:
23
3
2022
entrez:
3
4
2021
Statut:
ppublish
Résumé
Despite extended experimental and computational studies, the mechanism regulating membrane protein folding and stability in cell membranes is not fully understood. In this review, I will provide a personal and partial account of the scientific efforts undertaken by Dr. Stephen White to shed light on this topic. After briefly describing the role of water and the hydrophobic effect on cellular processes, I will discuss the physical chemistry of water confined inside the SecY translocon pore. I conclude with a review of recent literature that attempts to answer fundamental questions on the pathway and energetics of translocon-guided membrane protein insertion.
Identifiants
pubmed: 33811496
doi: 10.1007/s00232-021-00178-x
pii: 10.1007/s00232-021-00178-x
doi:
Substances chimiques
SEC Translocation Channels
0
Water
059QF0KO0R
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-139Références
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