Quantitative susceptibility mapping in the thalamus and basal ganglia of systemic lupus erythematosus patients with neuropsychiatric complaints.
Basal ganglia
Iron accumulation
Neuroinflammation
Neuropsychiatric systemic lupus erythematosus
Quantitative susceptibility mapping
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
10
2020
revised:
14
03
2021
accepted:
16
03
2021
pubmed:
4
4
2021
medline:
31
7
2021
entrez:
3
4
2021
Statut:
ppublish
Résumé
Systemic lupus erythematosus (SLE) is an auto-immune disease characterized by multi-organ involvement. Although uncommon, central nervous system involvement in SLE, termed neuropsychiatric SLE (NPSLE), is not an exception. Current knowledge on underlying pathogenic mechanisms is incomplete, however, neuroinflammation is thought to play a critical role. Evidence from neurodegenerative diseases and multiple sclerosis suggests that neuroinflammation is correlated with brain iron accumulation, making quantitative susceptibility mapping (QSM) a potential hallmark for neuroinflammation in vivo. This study assessed susceptibility values of the thalamus and basal ganglia in (NP)SLE patients and further investigated the in vivo findings with histological analyses of postmortem brain tissue derived from SLE patients. We used a 3T MRI scanner to acquire single-echo T
Identifiants
pubmed: 33812303
pii: S2213-1582(21)00081-4
doi: 10.1016/j.nicl.2021.102637
pmc: PMC8053812
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102637Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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