Biomarkers of phthalates and inflammation: Findings from a subgroup of Women's Health Initiative participants.
Biomarkers
CRP
Epidemiology
IL-6
Inflammation
Phthalates
Postmenopausal
Journal
International journal of hygiene and environmental health
ISSN: 1618-131X
Titre abrégé: Int J Hyg Environ Health
Pays: Germany
ID NLM: 100898843
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
03
11
2020
revised:
08
03
2021
accepted:
15
03
2021
pubmed:
5
4
2021
medline:
26
10
2021
entrez:
4
4
2021
Statut:
ppublish
Résumé
Recent experimental work has shown that phthalates may increase inflammation. Prior research has not examined the role of exposure to phthalates in relation to inflammatory status among postmenopausal women who are at higher risk of developing inflammation-related chronic disorders. We aimed to examine the associations of urinary phthalate biomarker concentrations with circulating levels of c-reactive protein [CRP] and interleukin-6 [IL-6] among 443 postmenopausal women selected into a breast cancer case-control study nested within the Women's Health Initiative (WHI). A total of 13 phthalate metabolites were measured in urine samples provided at WHI enrollment from 1993 to 1998. We also measured baseline levels of CRP and IL-6 in these women's serum or plasma samples. Multivariable linear models were used to investigate the role of each phthalate biomarker in relation to CRP and IL-6, adjusting for potential confounding factors and specifically evaluating the role of BMI. In adjusted models we observed positive associations of monocarboxynonyl phthalate (MCNP) with CRP (β = 0.092; 95% CI 0.026, 0.158) and IL-6 (β = 0.108; 95% CI 0.013, 0.204). These positive associations were attenuated and non-significant, however, after further adjustment for body mass index (BMI). In contrast, we observed inverse associations of monoethyl phthalate (MEP) (β = -0.019; 95% CI -0.036, -0.001) and monobenzyl phthalate (MBzP) (β = -0.034; 95% CI -0.058, -0.010) with CRP levels only after adjustment for BMI. Other phthalate biomarkers examined were not significantly associated with either CRP or IL-6 levels. Overall, these results do not suggest an important role for phthalates in promoting an inflammatory response. Future prospective studies are warranted to improve understanding of these associations, particularly in clarifying the role of BMI.
Sections du résumé
BACKGROUND
Recent experimental work has shown that phthalates may increase inflammation. Prior research has not examined the role of exposure to phthalates in relation to inflammatory status among postmenopausal women who are at higher risk of developing inflammation-related chronic disorders.
OBJECTIVES
We aimed to examine the associations of urinary phthalate biomarker concentrations with circulating levels of c-reactive protein [CRP] and interleukin-6 [IL-6] among 443 postmenopausal women selected into a breast cancer case-control study nested within the Women's Health Initiative (WHI).
METHODS
A total of 13 phthalate metabolites were measured in urine samples provided at WHI enrollment from 1993 to 1998. We also measured baseline levels of CRP and IL-6 in these women's serum or plasma samples. Multivariable linear models were used to investigate the role of each phthalate biomarker in relation to CRP and IL-6, adjusting for potential confounding factors and specifically evaluating the role of BMI.
RESULTS
In adjusted models we observed positive associations of monocarboxynonyl phthalate (MCNP) with CRP (β = 0.092; 95% CI 0.026, 0.158) and IL-6 (β = 0.108; 95% CI 0.013, 0.204). These positive associations were attenuated and non-significant, however, after further adjustment for body mass index (BMI). In contrast, we observed inverse associations of monoethyl phthalate (MEP) (β = -0.019; 95% CI -0.036, -0.001) and monobenzyl phthalate (MBzP) (β = -0.034; 95% CI -0.058, -0.010) with CRP levels only after adjustment for BMI. Other phthalate biomarkers examined were not significantly associated with either CRP or IL-6 levels.
CONCLUSIONS
Overall, these results do not suggest an important role for phthalates in promoting an inflammatory response. Future prospective studies are warranted to improve understanding of these associations, particularly in clarifying the role of BMI.
Identifiants
pubmed: 33813346
pii: S1438-4639(21)00058-4
doi: 10.1016/j.ijheh.2021.113743
pmc: PMC8096686
mid: NIHMS1688336
pii:
doi:
Substances chimiques
Biomarkers
0
Environmental Pollutants
0
Phthalic Acids
0
phthalic acid
6O7F7IX66E
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
113743Subventions
Organisme : NHLBI NIH HHS
ID : 75N92020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00005
Pays : United States
Organisme : CLC NIH HHS
ID : 75N90021D00004
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00001
Pays : United States
Organisme : CLC NIH HHS
ID : 75N90021D00002
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95021D00001
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00003
Pays : United States
Organisme : NIH HHS
ID : 75N98021D00005
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99021D00001
Pays : United States
Organisme : NLM NIH HHS
ID : 75N97021D00003
Pays : United States
Organisme : NICHD NIH HHS
ID : 75N94021D00002
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99021D00002
Pays : United States
Organisme : NICHD NIH HHS
ID : 75N94021D00001
Pays : United States
Organisme : NIH HHS
ID : 75N98021D00004
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00004
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES024731
Pays : United States
Organisme : NCI NIH HHS
ID : 75N91021D00001
Pays : United States
Organisme : NIH HHS
ID : 75N98021D00002
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier GmbH. All rights reserved.
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