Colon or Rectal Stent Positioning for Advanced Cancer Influences Quality of Life: A Critical Point of View.
Adenocarcinoma
/ pathology
Adult
Aged
Aged, 80 and over
Colonic Neoplasms
/ pathology
Digestive System Surgical Procedures
/ adverse effects
Disease Progression
Female
Follow-Up Studies
Humans
Intestinal Obstruction
/ etiology
Longitudinal Studies
Male
Middle Aged
Neoplasm Staging
Postoperative Complications
/ etiology
Quality of Life
Rectal Neoplasms
/ pathology
Self Expandable Metallic Stents
/ adverse effects
Treatment Outcome
Advanced colorectal cancer
endoscopic stent positioning
quality of life (QoL)
surgical resection
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
05
02
2021
revised:
01
03
2021
accepted:
02
03
2021
entrez:
4
4
2021
pubmed:
5
4
2021
medline:
28
4
2021
Statut:
ppublish
Résumé
Endoluminal self-expanding metallic stents (SEMS) may overcome the risk of mortality and morbidity of acute intestinal obstruction because of stage IV colon (CC) or rectal (RC) cancer. We evaluated the QoL in these groups of patients. Forty-eight patients were enrolled in a prospective longitudinal cohort single-center trial to undergo SEMS positioning. Twenty-five patients had a CC and 23 RC. Karnofsky performance scale, Visual Analogue Scale and the EQ-5D- 5L™ questionnaire were administered before treatment and at 1, 3 and 6 months. Harmonized to the Italian population, the index values showed a statistically significant deterioration of the QoL in patients with RC when compared to those with CC at 1-, 3- and 6-months (1 month: p=0.001; 3- month: p=0.001; 6-month: p=0.045). Similarly, Visual Analogue Scale showed variations at 1- (p=0.008), 3- (p=0.001) and 6-months (p=0.020). Rectal stent deployment was the only independent predictor for a worse QoL in all domains (p<0.017; OR=0.196; 95%CI=0.51-0.749). Patients affected with stage IV CC had a better QoL after SEMS placement when compared to those affected with RC. The persistency of the primary tumor at the rectal level, even if irradiated, might negatively affect QoL.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Endoluminal self-expanding metallic stents (SEMS) may overcome the risk of mortality and morbidity of acute intestinal obstruction because of stage IV colon (CC) or rectal (RC) cancer. We evaluated the QoL in these groups of patients.
PATIENTS AND METHODS
METHODS
Forty-eight patients were enrolled in a prospective longitudinal cohort single-center trial to undergo SEMS positioning. Twenty-five patients had a CC and 23 RC. Karnofsky performance scale, Visual Analogue Scale and the EQ-5D- 5L™ questionnaire were administered before treatment and at 1, 3 and 6 months.
RESULTS
RESULTS
Harmonized to the Italian population, the index values showed a statistically significant deterioration of the QoL in patients with RC when compared to those with CC at 1-, 3- and 6-months (1 month: p=0.001; 3- month: p=0.001; 6-month: p=0.045). Similarly, Visual Analogue Scale showed variations at 1- (p=0.008), 3- (p=0.001) and 6-months (p=0.020). Rectal stent deployment was the only independent predictor for a worse QoL in all domains (p<0.017; OR=0.196; 95%CI=0.51-0.749).
CONCLUSION
CONCLUSIONS
Patients affected with stage IV CC had a better QoL after SEMS placement when compared to those affected with RC. The persistency of the primary tumor at the rectal level, even if irradiated, might negatively affect QoL.
Identifiants
pubmed: 33813400
pii: 41/4/1945
doi: 10.21873/anticanres.14961
doi:
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM