Treatment Volume, Dose Prescription and Delivery Techniques for Dose-intensification in Rectal Cancer: A National Survey.

Female Humans Italy / epidemiology Lymphatic Metastasis Magnetic Resonance Imaging Male Neoplasm Staging Positron Emission Tomography Computed Tomography Positron-Emission Tomography Practice Patterns, Physicians' / statistics & numerical data Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted / adverse effects Radiotherapy, Image-Guided / adverse effects Radiotherapy, Intensity-Modulated / adverse effects Rectal Neoplasms / diagnosis Surveys and Questionnaires Survival Analysis Tumor Burden / physiology

Rectal cancer dose intensification gross tumor volume intensity modulated radiotherapy simultaneous integrated boost

Journal

Anticancer research

ISSN: 1791-7530

Titre abrégé: Anticancer Res

Pays: Greece

ID NLM: 8102988

Informations de publication

Date de publication:
Apr 2021

Historique:

received: 03 02 2021

revised: 01 03 2021

accepted: 03 03 2021

entrez: 4 4 2021

pubmed: 5 4 2021

medline: 28 4 2021

Statut: ppublish

Résumé

The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification. An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment). Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%). A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.

Sections du résumé

BACKGROUND/AIM OBJECTIVE

The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification.

PATIENTS AND METHODS METHODS

An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment).

RESULTS RESULTS

Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%).

CONCLUSION CONCLUSIONS

A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.

Identifiants

DOI: 10.21873/anticanres.14966 PMID: 33813405

pubmed: 33813405

pii: 41/4/1985

doi: 10.21873/anticanres.14966

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1985-1995