Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.
Dorsal motor nucleus of the vagus
Electron microscopy: whole-cell patch-clamp
Non-adrenergic non-cholinergic (NANC) pathways
Nucleus tractus solitarius
Optogenetics
Separate brainstem circuits
Somatostatin-GABA interneurons
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
31
10
2020
accepted:
18
03
2021
pubmed:
5
4
2021
medline:
1
4
2022
entrez:
4
4
2021
Statut:
ppublish
Résumé
This review is on how current knowledge of brainstem control of gastric mechanical function unfolded over nearly four decades from the perspective of our research group. It describes data from a multitude of different types of studies involving retrograde neuronal tracing, microinjection of drugs, whole-cell recordings from rodent brain slices, receptive relaxation reflex, accommodation reflex, c-Fos experiments, immunohistochemical methods, electron microscopy, transgenic mice, optogenetics, and GABAergic signaling. Data obtained indicate the following: (1) nucleus tractus solitarius (NTS)-dorsal motor nucleus of the vagus (DMV) noradrenergic connection is required for reflex control of the fundus; (2) second-order nitrergic neurons in the NTS are also required for reflex control of the fundus; (3) a NTS GABAergic connection is required for reflex control of the antrum; (4) a single DMV efferent pathway is involved in brainstem control of gastric mechanical function under most experimental conditions excluding the accommodation reflex. Dual-vagal effectors controlling cholinergic and non-adrenergic and non-cholinergic (NANC) input to the stomach may be part of the circuitry of this reflex. (5) GABAergic signaling within the NTS via Sst-GABA interneurons determine the basal (resting) state of gastric tone and phasic contractions. (6) For the vagal-vagal reflex to become operational, an endogenous opioid in the NTS is released and the activity of Sst-GABA interneurons is suppressed. From the data, we suggest that the CNS has the capacity to provide region-specific control over the proximal (fundus) and distal (antrum) stomach through engaging phenotypically different efferent inputs to the DMV.
Identifiants
pubmed: 33813668
doi: 10.1007/s10571-021-01084-5
pii: 10.1007/s10571-021-01084-5
pmc: PMC9595174
mid: NIHMS1841876
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-360Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK117508
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK117508
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK117508
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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