Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar.
diet
hormonal contraceptives
menstrual cycle
oral microbiome
saliva
shotgun sequencing
sugar
women’s health
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
11
2020
accepted:
11
02
2021
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
6
7
2021
Statut:
epublish
Résumé
Physiological hormonal fluctuations exert endogenous pressures on the structure and function of the human microbiome. As such, the menstrual cycle may selectively disrupt the homeostasis of the resident oral microbiome, thus compromising oral health. Hence, the aim of the present study was to structurally and functionally profile the salivary microbiome of 103 women in reproductive age with regular menstrual cycle, while evaluating the modifying influences of hormonal contraceptives, sex hormones, diet, and smoking. Whole saliva was sampled during the menstrual, follicular, and luteal phases (n = 309) of the cycle, and the participants reported questionnaire-based data concerning their life habits and oral or systemic health. No significant differences in alpha-diversity or phase-specific clustering of the overall microbiome were observed. Nevertheless, the salivary abundances of genera
Identifiants
pubmed: 33816334
doi: 10.3389/fcimb.2021.625229
pmc: PMC8018275
doi:
Substances chimiques
Dietary Sugars
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
625229Informations de copyright
Copyright © 2021 Bostanci, Krog, Hugerth, Bashir, Fransson, Boulund, Belibasakis, Wannerberger, Engstrand, Nielsen and Schuppe-Koistinen.
Déclaration de conflit d'intérêts
Author KW was employed by Ferring International Center SA. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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