Is neuroticism differentially associated with risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia?
Alzheimer's disease
Emotional distress
Neurodegenerative disease
Personality
Pick's disease
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
25
01
2021
revised:
10
03
2021
accepted:
19
03
2021
pubmed:
6
4
2021
medline:
6
7
2021
entrez:
5
4
2021
Statut:
ppublish
Résumé
This study examines whether neuroticism is differentially associated with risk of incident Alzheimer's disease (AD), vascular dementia (VD), and frontotemporal dementia (FTD) using a prospective study design. Participants from the UK Biobank (N = 401,422) completed a self-report neuroticism scale in 2006-2010 and incident all-cause dementia, AD, VD, and FTD were ascertained using electronic health records or death records up to 2018. During an average follow-up of 8.8 years (3,566,123 person-years), there were 1798 incident of all-cause dementia, 675 AD, 376 VD, and 81 FTD. Accounting for age and sex, compared to individuals in the low quartile, individuals in the top quartile of neuroticism had higher risk of all-cause dementia (HR = 1.70; 95% CI: 1.49-1.93), AD (HR = 1.42; 1.15-1.75), VD (HR = 1.73; 1.30-2.29), but not FTD (HR = 0.89; 0.49-1.63). The associations with AD and VD were attenuated but remained significant after further accounting for education, household income, deprivation index, diabetes, hypertension, stroke, heart attack, ever smoker, physical activity, obesity, hemoglobin A1c, C-reactive protein, and low-density lipoprotein. The associations were not moderated by socioeconomic status. The findings were consistent in analyses that excluded cases that occurred within the first 5 years of follow-up. In conclusion, neuroticism is a robust predictor of incident AD and VD, but not FTD. This pattern suggests that the affective symptoms that distinguish dementia types may partly reflect premorbid differences in trait neuroticism.
Identifiants
pubmed: 33819874
pii: S0022-3956(21)00189-8
doi: 10.1016/j.jpsychires.2021.03.039
pmc: PMC8192471
mid: NIHMS1696444
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-40Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG068093
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053297
Pays : United States
Organisme : British Heart Foundation
ID : CH/1996001/9454
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P01271X/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R21 AG057917
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Eur J Epidemiol. 2019 Jun;34(6):557-565
pubmed: 30806901
Addiction. 2015 Nov;110(11):1844-52
pubmed: 26227786
Arch Gen Psychiatry. 2012 May;69(5):493-8
pubmed: 22566581
PLoS One. 2013;8(1):e54746
pubmed: 23372763
Health Psychol. 2008 May;27(3):369-78
pubmed: 18624602
JAMA Psychiatry. 2020 Feb 1;77(2):148-154
pubmed: 31617877
J Gerontol B Psychol Sci Soc Sci. 2013 Nov;68(6):912-20
pubmed: 23685925
Neurology. 2014 Oct 21;83(17):1538-44
pubmed: 25274849
J Gerontol B Psychol Sci Soc Sci. 2020 Feb 14;75(3):513-521
pubmed: 29846724
J Psychosom Res. 2010 Aug;69(2):193-201
pubmed: 20624519
J Am Geriatr Soc. 2020 Apr;68(4):803-808
pubmed: 31880326
Assessment. 2020 Jul;27(5):982-995
pubmed: 29993260
Brain Imaging Behav. 2020 Dec;14(6):2122-2131
pubmed: 31486975
J Int Neuropsychol Soc. 2020 Jul;26(6):596-606
pubmed: 31822309
Br J Psychiatry. 2011 May;198(5):365-72
pubmed: 21372059
J Int Neuropsychol Soc. 2016 Aug;22(7):765-76
pubmed: 27346168
Addict Behav. 2020 Nov;110:106503
pubmed: 32622028
Neurology. 1998 Dec;51(6):1546-54
pubmed: 9855500
Alzheimers Dement. 2019 Dec;15(12):1546-1557
pubmed: 31619348
Alzheimers Dement. 2017 Jan;13(1):28-37
pubmed: 27172148
Acta Neurol Scand. 2001 Jun;103(6):367-78
pubmed: 11421849
Psychol Sci. 2021 Jul;32(7):1047-1057
pubmed: 34081568
Neurology. 2017 Jan 24;88(4):371-378
pubmed: 27986873
J Gerontol B Psychol Sci Soc Sci. 2020 Jan 14;75(2):263-273
pubmed: 29590450
JAMA Psychiatry. 2017 Dec 1;74(12):1259-1265
pubmed: 28975188
Neuroimage. 2009 Sep;47(3):864-71
pubmed: 19500680
Aging (Albany NY). 2018 Aug 06;10(8):1791-1792
pubmed: 30082505
Neurology. 2005 Jan 25;64(2):380-2
pubmed: 15668449
Ageing Res Rev. 2021 May;67:101269
pubmed: 33561581
Neuropsychopharmacology. 2004 Apr;29(4):795-8
pubmed: 14735133
J Alzheimers Dis. 2019;69(4):1099-1108
pubmed: 31156171
Alzheimer Dis Assoc Disord. 2013 Jul-Sep;27(3):258-64
pubmed: 23060360
J Res Pers. 2016 Aug;63:22-28
pubmed: 29056783
Am J Geriatr Psychiatry. 2014 Sep;22(9):917-25
pubmed: 23759291
Alzheimers Dement. 2014 Mar;10(2):179-86
pubmed: 23706517
Int J Geriatr Psychiatry. 2018 Mar;33(3):489-494
pubmed: 28869657
J Gerontol B Psychol Sci Soc Sci. 2021 Jan 1;76(1):6-19
pubmed: 32969474
Psychosom Med. 2011 Oct;73(8):638-42
pubmed: 21949427
J Am Med Dir Assoc. 2019 Feb;20(2):131-137
pubmed: 30630729
Neurobiol Aging. 2011 Dec;32(12):2162-71
pubmed: 20036035
Neurobiol Aging. 2013 Apr;34(4):1045-50
pubmed: 23040035
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Personal Disord. 2019 Jan;10(1):4-12
pubmed: 30604979
Int J Psychophysiol. 2019 Oct;144:34-39
pubmed: 31229589
Neurosci Biobehav Rev. 2017 Jun;77:74-86
pubmed: 28254428
J Pers Soc Psychol. 1999 Nov;77(5):1087-100
pubmed: 10573882