Biologically consistent dose accumulation using daily patient imaging.
Delivered dose
Dose accumulation
Image guidance
Linear quadratic model
Normal tissue response
Radiobiology
Journal
Radiation oncology (London, England)
ISSN: 1748-717X
Titre abrégé: Radiat Oncol
Pays: England
ID NLM: 101265111
Informations de publication
Date de publication:
06 Apr 2021
06 Apr 2021
Historique:
received:
29
05
2020
accepted:
17
03
2021
entrez:
7
4
2021
pubmed:
8
4
2021
medline:
19
11
2021
Statut:
epublish
Résumé
This work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the linear quadratic model (LQM). To overcome this inconsistency, we introduce and evaluate the concept of the total biological dose, bEQD Daily computed tomography imaging of nine patients treated for prostate carcinoma with intensity-modulated radiotherapy was used to compute the delivered deformed dose on the basis of deformable image registration (DIR). We compared conventional dose accumulation (DA) with the newly introduced bEQD bEQD Using bEQD
Sections du résumé
BACKGROUND
BACKGROUND
This work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the linear quadratic model (LQM). To overcome this inconsistency, we introduce and evaluate the concept of the total biological dose, bEQD
METHODS
METHODS
Daily computed tomography imaging of nine patients treated for prostate carcinoma with intensity-modulated radiotherapy was used to compute the delivered deformed dose on the basis of deformable image registration (DIR). We compared conventional dose accumulation (DA) with the newly introduced bEQD
RESULTS
RESULTS
bEQD
CONCLUSION
CONCLUSIONS
Using bEQD
Identifiants
pubmed: 33823885
doi: 10.1186/s13014-021-01789-3
pii: 10.1186/s13014-021-01789-3
pmc: PMC8025323
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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