Important role of Nfkb2 in the Kras

Animals Carcinogenesis / genetics Carcinoma, Pancreatic Ductal / genetics Genes, ras Mice Pancreas Pancreatic Neoplasms / genetics Proto-Oncogene Proteins p21(ras) / genetics
Kras NFκB2 Pancreatic cancer

Journal

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ISSN: 1424-3911
Titre abrégé: Pancreatology
Pays: Switzerland
ID NLM: 100966936

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 29 01 2021
revised: 11 03 2021
accepted: 17 03 2021
pubmed: 8 4 2021
medline: 6 1 2022
entrez: 7 4 2021
Statut: ppublish

Résumé

Oncogenic Kras initiates and drives carcinogenesis in the pancreas by complex signaling networks, including activation of the NFκB pathway. Although recent evidence has shown that oncogenic gains in Nfκb2 collaborate with Kras in the carcinogenesis, no data at the level of genetics for the contribution of Nfκb2 is available so far. We used Nfkb2 knock-out mice to decipher the role of the gene in Kras-driven carcinogenesis in vivo. We show that the Nfkb2 gene is needed for cancer initiation and progression in Kras Our data add to the understanding of context-dependent requirements of oncogenic Kras signaling during pancreatic carcinogenesis.

Sections du résumé

BACKGROUND BACKGROUND
Oncogenic Kras initiates and drives carcinogenesis in the pancreas by complex signaling networks, including activation of the NFκB pathway. Although recent evidence has shown that oncogenic gains in Nfκb2 collaborate with Kras in the carcinogenesis, no data at the level of genetics for the contribution of Nfκb2 is available so far.
METHODS METHODS
We used Nfkb2 knock-out mice to decipher the role of the gene in Kras-driven carcinogenesis in vivo.
RESULTS RESULTS
We show that the Nfkb2 gene is needed for cancer initiation and progression in Kras
CONCLUSIONS CONCLUSIONS
Our data add to the understanding of context-dependent requirements of oncogenic Kras signaling during pancreatic carcinogenesis.

Identifiants

DOI: 10.1016/j.pan.2021.03.012 PMID: 33824054
pubmed: 33824054
pii: S1424-3903(21)00106-X
doi: 10.1016/j.pan.2021.03.012
pii:
doi:

Substances chimiques

Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

912-919

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Zonera Hassan (Z)

Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, 81675, München, Germany.

Christian Schneeweis (C)

Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, 81675, München, Germany.

Matthias Wirth (M)

Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Sebastian Müller (S)

Institute of Molecular Oncology and Functional Genomics, Technical University Munich, 81675, München, Germany.

Claudia Geismann (C)

Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Internal Medicine, University Hospital Schleswig-Holstein, 24105, Kiel, Germany.

Thorsten Neuß (T)

Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, 81675, München, Germany.

Katja Steiger (K)

Institute of Pathology, Technische Universität München, 81675, München, Germany; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.

Oliver H Krämer (OH)

Department of Toxicology, University of Mainz Medical Center, 55131, Mainz, Germany.

Roland M Schmid (RM)

Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, 81675, München, Germany.

Roland Rad (R)

Institute of Molecular Oncology and Functional Genomics, Technical University Munich, 81675, München, Germany; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.

Alexander Arlt (A)

Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Internal Medicine, University Hospital Schleswig-Holstein, 24105, Kiel, Germany; University Department for Gastroenterology, Klinikum Oldenburg AöR, European Medical School (EMS), 26133, Oldenburg, Germany.

Maximilian Reichert (M)

Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, 81675, München, Germany; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany; Center for Protein Assemblies (CPA), Technische Universität München, 85747, Garching, Germany.

Dieter Saur (D)

German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany; Institute for Translational Cancer Research and Experimental Cancer Therapy, Technical University Munich, 81675, München, Germany.

Günter Schneider (G)

Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, 81675, München, Germany; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany. Electronic address: guenter.schneider@tum.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Important role of Nfkb2 in the Kras
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Important role of Nfkb2 in the Kras
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Important role of Nfkb2 in the Kras
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Proto-oncogènes › Gènes ras › Important role of Nfkb2 in the Kras
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Important role of Nfkb2 in the Kras
questionsmedicales.fr › Système digestif › Pancréas › Important role of Nfkb2 in the Kras
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Important role of Nfkb2 in the Kras
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Important role of Nfkb2 in the Kras