Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu

Prefrontal Cortex Synapses Synaptic Transmission

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
06 04 2021
Historique:
entrez: 7 4 2021
pubmed: 8 4 2021
medline: 14 1 2022
Statut: epublish

Résumé

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies have suggested that mGluRs can form functional heterodimers in cell lines. Using selective allosteric ligands, ex vivo brain slice electrophysiology, and optogenetic approaches, we found that two mGluR subtypes-mGluR2 and mGluR4 (or mGlu

Identifiants

DOI: 10.1126/scisignal.abd2319 PMID: 33824180 PMC: PMC8279257
pubmed: 33824180
pii: 14/677/eabd2319
doi: 10.1126/scisignal.abd2319
pmc: PMC8279257
mid: NIHMS1714035
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS031373
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS113614
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108498
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS031373
Pays : United States

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Zixiu Xiang (Z)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0002-1678-209X

Xiaohui Lv (X)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.

Xin Lin (X)

Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
ORCID: 0000-0003-1867-1833

Daniel E O'Brien (DE)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.

Molly K Altman (MK)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.

Craig W Lindsley (CW)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0003-0168-1445

Jonathan A Javitch (JA)

Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032, USA.
ORCID: 0000-0001-7395-2967

Colleen M Niswender (CM)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0001-6009-8212

P Jeffrey Conn (PJ)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA. jeff.conn@vanderbilt.edu.
Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0003-2363-0323

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › Input-specific regulation of glutamatergic...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Input-specific regulation of glutamatergic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Input-specific regulation of glutamatergic...