New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells.


Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
19 05 2021
Historique:
received: 29 09 2020
revised: 19 03 2021
accepted: 27 03 2021
pubmed: 8 4 2021
medline: 19 11 2021
entrez: 7 4 2021
Statut: ppublish

Résumé

Transmembrane channel-like protein isoform 1 (TMC1) is a major component of the mechano-electrical transducer (MET) channel in cochlear hair cells and is subject to numerous mutations causing deafness. We report a new dominant human deafness mutation,

Identifiants

pubmed: 33824189
pii: JNEUROSCI.2537-20.2021
doi: 10.1523/JNEUROSCI.2537-20.2021
pmc: PMC8152607
doi:

Substances chimiques

Membrane Proteins 0
TMC1 protein, human 0
TMC1 protein, mouse 0

Banques de données

PDB
['4WIS']

Types de publication

Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4378-4391

Subventions

Organisme : NIDCD NIH HHS
ID : R01 DC001362
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015439
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 NS002945
Pays : United States

Informations de copyright

Copyright © 2021 Beurg et al.

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Auteurs

Maryline Beurg (M)

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706.

Lisa A Schimmenti (LA)

Departments of Clinical Genomics, Otorhinolaryngology, Head and Neck Surgery and Biochemistry and Molecular Biology, Mayo Clinic School of Medicine, Rochester, Minnesota 55902.

Alaa Koleilat (A)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55902.

Sami S Amr (SS)

Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge, Massachusetts 02139.
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Andrea Oza (A)

Partners HealthCare Personalized Medicine, Laboratory for Molecular Medicine, Cambridge, Massachusetts 02139.

Amanda J Barlow (AJ)

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706.

Angela Ballesteros (A)

Molecular Physiology and Biophysics section, National Institute of Neurological Disorders and Stroke-National Institutes of Health, Bethesda, Maryland 20892.

Robert Fettiplace (R)

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 fettiplace@wisc.edu.

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