The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery.
best practices
modes of action
phenotypic
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
18
01
2021
pubmed:
8
4
2021
medline:
27
1
2022
entrez:
7
4
2021
Statut:
ppublish
Résumé
Phenotypic drug discovery has a long track record of delivering innovative drugs and has received renewed attention in the last few years. The promise of this approach, however, comes with several challenges that should be addressed to avoid wasting time and resources on drugs with undesired modes of action or, worse, false-positive hits. In this set of best practices, we go over the essential steps of phenotypic drug discovery and provide guidance on how to increase the chance of success in identifying validated and relevant chemical starting points for optimization: selecting the right assay, selecting the right compound screening library and developing appropriate hit validation assays. Then, we highlight the importance of initiating studies to determine the mode of action of the identified hits early and present the current state of the art.
Identifiants
pubmed: 33825353
doi: 10.1002/cmdc.202100041
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1736-1739Subventions
Organisme : EFMC
Informations de copyright
© 2021 Wiley-VCH GmbH.
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Slide decks and webinars on the best practices and case studies are freely accesible on https://www.efmc.info/phenotypic-drug-discovery.
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