Gianluca Sbardella

Affiliations

Department of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, Via Giovanni Paolo II 132, I-84084, Fisciano, Salerno, Italy. Electronic address: gsbardella@unisa.it.

Publications (18)

Targeting epigenetic reader domains by chemical biology.

Current opinion in chemical biology

Avec: Alessandra Cipriano , Gianluca Sbardella , Alessio Ciulli

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.

Journal of medicinal chemistry

Avec: Giulia Iannelli , Ciro Milite , Nils Marechal , Vincent Cura , Luc Bonnefond , Nathalie Troffer-Charlier , Alessandra Feoli , Donatella Rescigno , Yalong Wang , Alessandra Cipriano , Monica Viviano , Mark T Bedford , Jean Cavarelli , Sabrina Castellano , Gianluca Sbardella

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8.

Journal of medicinal chemistry

Avec: Francesco Fiorentino , Sara Sementilli , Martina Menna , Federica Turrisi , Stefano Tomassi , Francesca Romana Pellegrini , Angela Iuzzolino , Francesca D'Acunzo , Alessandra Feoli , Hannah Wapenaar , Sophie Taraglio , Caterina Fraschetti , Donatella Del Bufalo , Gianluca Sbardella , Frank J Dekker , Alessandro Paiardini , Daniela Trisciuoglio , Antonello Mai , Dante Rotili

NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.

Journal of medicinal chemistry

Avec: Alessandra Cipriano , Monica Viviano , Alessandra Feoli , Ciro Milite , Giuliana Sarno , Sabrina Castellano , Gianluca Sbardella

The Chemical Biology-Medicinal Chemistry Continuum: EFMC's Vision.

Chembiochem : a European journal of chemical biology

Avec: Maria Duca , Dennis Gillingham , Christian Adam Olsen , Gianluca Sbardella , Philip R Skaanderup , Mario van der Stelt , Boris Vauzeilles , Olalla Vázquez , Yves P Auberson

Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice.

Learning & memory (Cold Spring Harbor, N.Y.)

Avec: Samantha D Creighton , Kristen H Jardine , Alexa Desimone , Megan Zmetana , Sabrina Castellano , Ciro Milite , Gianluca Sbardella , Boyer D Winters

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.

European journal of medicinal chemistry

Avec: Giulia Stazi , Cecilia Battistelli , Valentina Piano , Roberta Mazzone , Biagina Marrocco , Sara Marchese , Sharon M Louie , Clemens Zwergel , Lorenzo Antonini , Alexandros Patsilinakos , Rino Ragno , Monica Viviano , Gianluca Sbardella , Alessia Ciogli , Giancarlo Fabrizi , Roberto Cirilli , Raffaele Strippoli , Alessandra Marchetti , Marco Tripodi , Daniel K Nomura , Andrea Mattevi , Antonello Mai , Sergio Valente

DMSO-Related Effects on Ligand-Binding Properties of Lysine Methyltransferases G9a and SETD8.

Chembiochem : a European journal of chemical biology

Avec: Alessandra Feoli , Giuliana Sarno , Sabrina Castellano , Gianluca Sbardella

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.

Journal of medicinal chemistry

Avec: Alessandra Feoli , Giulia Iannelli , Alessandra Cipriano , Ciro Milite , Lei Shen , Zhihao Wang , Andrea Hadjikyriacou , Troy L Lowe , Cyrus Safaeipour , Monica Viviano , Giuliana Sarno , Elva Morretta , Maria Chiara Monti , Yanzhong Yang , Steven G Clarke , Sandro Cosconati , Sabrina Castellano , Gianluca Sbardella

Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.

ChemMedChem

Avec: Ciro Milite , Giuliana Sarno , Ida Pacilio , Agostino Cianciulli , Monica Viviano , Giulia Iannelli , Erica Gazzillo , Alessandra Feoli , Alessandra Cipriano , Maria Giovanna Chini , Sabrina Castellano , Giuseppe Bifulco , Gianluca Sbardella

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male - but not Female - Rats to Enhance Short-term Memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Krista A Mitchnick , Kate Nicholson , Cassidy Wideman , Kristen Jardine , Rhiannon Jamieson-Williams , Samantha D Creighton , Allison Lacoursiere , Ciro Milite , Sabrina Castellano , Gianluca Sbardella , Neil J MacLusky , Elena Choleris , Boyer D Winters

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery.

ChemMedChem

Avec: Jean Quancard , Anders Bach , Brian Cox , Russell Craft , Dirk Finsinger , Stéphanie M Guéret , Ingo V Hartung , Stefan Laufer , Josef Messinger , Gianluca Sbardella , Hannes F Koolman

Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.

Journal of medicinal chemistry

Avec: Ciro Milite , Alessandra Feoli , John R Horton , Donatella Rescigno , Alessandra Cipriano , Vincenzo Pisapia , Monica Viviano , Giacomo Pepe , Giorgio Amendola , Ettore Novellino , Sandro Cosconati , Xiaodong Cheng , Sabrina Castellano , Gianluca Sbardella

Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence.

Epigenetics

Avec: Lucia Scisciola , Federica Sarno , Vincenzo Carafa , Sandro Cosconati , Salvatore Di Maro , Loreta Ciuffreda , Antonella De Angelis , Paola Stiuso , Alessandra Feoli , Gianluca Sbardella , Lucia Altucci , Angela Nebbioso

The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes.

ChemMedChem

Avec: Jean Quancard , Brian Cox , Dirk Finsinger , Stéphanie M Guéret , Ingo V Hartung , Hannes F Koolman , Josef Messinger , Gianluca Sbardella , Stefan Laufer

Lysine methyltransferase inhibitors: where we are now.

RSC chemical biology

Avec: Alessandra Feoli , Monica Viviano , Alessandra Cipriano , Ciro Milite , Sabrina Castellano , Gianluca Sbardella

Successes and challenges in the development of BD1-selective BET inhibitors: a patent review.

Expert opinion on therapeutic patents

Avec: Monica Viviano , Alessandra Cipriano , Emanuele Fabbrizi , Alessandra Feoli , Sabrina Castellano , Gianluca Sbardella , Antonello Mai , Ciro Milite , Dante Rotili

Discovery of Benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain.

ChemMedChem

Avec: Alessandra Cipriano , Ciro Milite , Alessandra Feoli , Monica Viviano , Giacomo Pepe , Pietro Campiglia , Giuliana Sarno , Sarah Picaud , Satomi Imaide , Nikolai Makukhin , Panagis Filippakopoulos , Alessio Ciulli , Sabrina Castellano , Gianluca Sbardella

Réseau de co-auteurs

Alessandra Feoli 11 collaborations

Sabrina Castellano 11 collaborations

Ciro Milite 10 collaborations

Alessandra Cipriano 9 collaborations

Monica Viviano 9 collaborations

Giuliana Sarno 5 collaborations

Giulia Iannelli 3 collaborations

Antonello Mai 3 collaborations

Sandro Cosconati 3 collaborations

Alessio Ciulli 2 collaborations

Donatella Rescigno 2 collaborations

Dante Rotili 2 collaborations

Samantha D Creighton 2 collaborations

Boyer D Winters 2 collaborations

Jean Quancard 2 collaborations

Brian Cox 2 collaborations

Dirk Finsinger 2 collaborations

Stéphanie M Guéret 2 collaborations

Ingo V Hartung 2 collaborations

Stefan Laufer 2 collaborations

Josef Messinger 2 collaborations

Hannes F Koolman 2 collaborations

Giacomo Pepe 2 collaborations

Nils Marechal 1 collaboration

Vincent Cura 1 collaboration

Luc Bonnefond 1 collaboration

Nathalie Troffer-Charlier 1 collaboration

Yalong Wang 1 collaboration

Mark T Bedford 1 collaboration

Jean Cavarelli 1 collaboration

Francesco Fiorentino 1 collaboration

Sara Sementilli 1 collaboration

Martina Menna 1 collaboration

Federica Turrisi 1 collaboration

Stefano Tomassi 1 collaboration

Francesca Romana Pellegrini 1 collaboration

Angela Iuzzolino 1 collaboration

Francesca D'Acunzo 1 collaboration

Hannah Wapenaar 1 collaboration

Sophie Taraglio 1 collaboration

Caterina Fraschetti 1 collaboration

Donatella Del Bufalo 1 collaboration

Frank J Dekker 1 collaboration

Alessandro Paiardini 1 collaboration

Daniela Trisciuoglio 1 collaboration

Maria Duca 1 collaboration

Dennis Gillingham 1 collaboration

Christian Adam Olsen 1 collaboration

Philip R Skaanderup 1 collaboration

Mario van der Stelt 1 collaboration

Boris Vauzeilles 1 collaboration

Olalla Vázquez 1 collaboration

Yves P Auberson 1 collaboration

Kristen H Jardine 1 collaboration

Alexa Desimone 1 collaboration

Megan Zmetana 1 collaboration

Giulia Stazi 1 collaboration

Cecilia Battistelli 1 collaboration

Valentina Piano 1 collaboration

Roberta Mazzone 1 collaboration

Biagina Marrocco 1 collaboration

Sara Marchese 1 collaboration

Sharon M Louie 1 collaboration

Clemens Zwergel 1 collaboration

Lorenzo Antonini 1 collaboration

Alexandros Patsilinakos 1 collaboration

Rino Ragno 1 collaboration

Alessia Ciogli 1 collaboration

Giancarlo Fabrizi 1 collaboration

Roberto Cirilli 1 collaboration

Raffaele Strippoli 1 collaboration

Alessandra Marchetti 1 collaboration

Marco Tripodi 1 collaboration

Daniel K Nomura 1 collaboration

Andrea Mattevi 1 collaboration

Sergio Valente 1 collaboration

Lei Shen 1 collaboration

Zhihao Wang 1 collaboration

Andrea Hadjikyriacou 1 collaboration

Troy L Lowe 1 collaboration

Cyrus Safaeipour 1 collaboration

Elva Morretta 1 collaboration

Maria Chiara Monti 1 collaboration

Yanzhong Yang 1 collaboration

Steven G Clarke 1 collaboration

Ida Pacilio 1 collaboration

Agostino Cianciulli 1 collaboration

Erica Gazzillo 1 collaboration

Maria Giovanna Chini 1 collaboration

Giuseppe Bifulco 1 collaboration

Krista A Mitchnick 1 collaboration

Kate Nicholson 1 collaboration

Cassidy Wideman 1 collaboration

Kristen Jardine 1 collaboration

Rhiannon Jamieson-Williams 1 collaboration

Allison Lacoursiere 1 collaboration

Neil J MacLusky 1 collaboration

Elena Choleris 1 collaboration

Anders Bach 1 collaboration

Russell Craft 1 collaboration

John R Horton 1 collaboration

Vincenzo Pisapia 1 collaboration

Giorgio Amendola 1 collaboration

Ettore Novellino 1 collaboration

Xiaodong Cheng 1 collaboration

Lucia Scisciola 1 collaboration

Federica Sarno 1 collaboration

Vincenzo Carafa 1 collaboration

Salvatore Di Maro 1 collaboration

Loreta Ciuffreda 1 collaboration

Antonella De Angelis 1 collaboration

Paola Stiuso 1 collaboration

Lucia Altucci 1 collaboration

Angela Nebbioso 1 collaboration

Emanuele Fabbrizi 1 collaboration

Pietro Campiglia 1 collaboration

Sarah Picaud 1 collaboration

Satomi Imaide 1 collaboration

Nikolai Makukhin 1 collaboration

Panagis Filippakopoulos 1 collaboration