Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice.
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN: 1549-5485
Titre abrégé: Learn Mem
Pays: United States
ID NLM: 9435678
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
13
10
2021
accepted:
04
01
2022
entrez:
16
2
2022
pubmed:
17
2
2022
medline:
20
4
2022
Statut:
epublish
Résumé
Histone acetylation, catalyzed by histone acetyltransferases, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional manner. At 3 and 6 mo of age, PCAF activation ameliorated memory deficits. At 9 mo of age, PCAF activation had no effect on spatial memory, whereas PCAF inhibition improved memory deficits in females. This work reveals a complex potential therapeutic role for PCAF in AD, initially benefitting memory but becoming detrimental as the disease progresses.
Identifiants
pubmed: 35169045
pii: 29/3/71
doi: 10.1101/lm.053536.121
pmc: PMC8852226
doi:
Substances chimiques
Histone Acetyltransferases
EC 2.3.1.48
p300-CBP Transcription Factors
EC 2.3.1.48
p300-CBP-associated factor
EC 2.3.1.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
71-76Informations de copyright
© 2022 Creighton et al.; Published by Cold Spring Harbor Laboratory Press.
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