Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study.
Aged
Atrophy
/ blood
Austria
Brain
/ diagnostic imaging
Chromatography, Liquid
Cognition
/ physiology
Executive Function
/ physiology
Female
Humans
Magnetic Resonance Imaging
Male
Memory
/ physiology
Middle Aged
Neuropsychological Tests
Stroke
/ prevention & control
Tandem Mass Spectrometry
Vitamin D
/ analogs & derivatives
LC-MS/MS
cognitive function
dementia
memory
vitamin D metabolites
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
07 04 2021
07 04 2021
Historique:
received:
09
02
2021
accepted:
27
03
2021
pubmed:
8
4
2021
medline:
17
8
2021
entrez:
7
4
2021
Statut:
ppublish
Résumé
Vitamin D is a well-established regulator of calcium and phosphate metabolism that has neurotrophic and neuroprotective properties. Deficiency of vitamin D has been proposed to promote cognitive dysfunction and brain atrophy. However, existing studies provide inconsistent results. Here we aimed to investigate the association between vitamin D metabolites, cognitive function and brain atrophy in a cohort of well-characterized community-dwelling elderly individuals with normal neurological status and without history of stroke and dementia. 25(OH)D Total 25(OH)D (ß=0.003, 0.037), 24,25(OH) Vitamin D deficient individuals appear to have a modest reduction of memory function without structural brain atrophy. Future studies should explore if vitamin D supplementation can improve cognitive function.
Sections du résumé
BACKGROUND
Vitamin D is a well-established regulator of calcium and phosphate metabolism that has neurotrophic and neuroprotective properties. Deficiency of vitamin D has been proposed to promote cognitive dysfunction and brain atrophy. However, existing studies provide inconsistent results. Here we aimed to investigate the association between vitamin D metabolites, cognitive function and brain atrophy in a cohort of well-characterized community-dwelling elderly individuals with normal neurological status and without history of stroke and dementia.
METHODS
25(OH)D
RESULTS
Total 25(OH)D (ß=0.003, 0.037), 24,25(OH)
CONCLUSIONS
Vitamin D deficient individuals appear to have a modest reduction of memory function without structural brain atrophy. Future studies should explore if vitamin D supplementation can improve cognitive function.
Identifiants
pubmed: 33825696
pii: 202930
doi: 10.18632/aging.202930
pmc: PMC8064143
doi:
Substances chimiques
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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