Identification, Characterization, and Suppression of Side Products Formed during the Synthesis of [


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 04 2021
Historique:
pubmed: 8 4 2021
medline: 16 6 2021
entrez: 7 4 2021
Statut: ppublish

Résumé

In recent years, radiolabeled tracers targeting prostate-specific membrane antigen (PSMA) have had a tremendous impact on prostate cancer management. Here, we report on the formation of radioactive impurities formed during the clinical production of

Identifiants

pubmed: 33826320
doi: 10.1021/acs.jmedchem.1c00045
doi:

Substances chimiques

Dipeptides 0
Heterocyclic Compounds, 1-Ring 0
PSMA-617 0
Radioisotopes 0
Radiopharmaceuticals 0
Lutetium 5H0DOZ21UJ
Lutetium-177 BRH40Y9V1Q
Prostate-Specific Antigen EC 3.4.21.77

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4960-4971

Auteurs

Sebastian Martin (S)

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.
Department of Nuclear Medicine, Medical Center-University of Freiburg, D-79106 Freiburg, Germany.
Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Rue de Bugnon 25A, CH-1011 Lausanne, Switzerland.

Roswitha Tönnesmann (R)

Department of Nuclear Medicine, Medical Center-University of Freiburg, D-79106 Freiburg, Germany.

Ina Hierlmeier (I)

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.

Stephan Maus (S)

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.

Florian Rosar (F)

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.

Juri Ruf (J)

Department of Nuclear Medicine, Medical Center-University of Freiburg, D-79106 Freiburg, Germany.

Jason P Holland (JP)

Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

Samer Ezziddin (S)

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.

Mark D Bartholomä (MD)

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.
Department of Nuclear Medicine, Medical Center-University of Freiburg, D-79106 Freiburg, Germany.

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Classifications MeSH