Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.
Aged
Aged, 80 and over
Alzheimer Disease
/ physiopathology
Brain Mapping
Electroencephalography
Emotions
/ physiology
Evoked Potentials
/ physiology
Facial Recognition
Female
Frontotemporal Dementia
/ physiopathology
Humans
Interoception
/ physiology
Male
Middle Aged
Nerve Degeneration
/ physiopathology
Neural Pathways
/ physiology
Parkinson Disease
/ physiopathology
Psychomotor Performance
/ physiology
Alzheimer's disease
Parkinson's disease
behavioral variant frontotemporal dementia
emotion
interoception
priming
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
12 05 2021
12 05 2021
Historique:
received:
07
08
2020
revised:
17
03
2021
accepted:
18
03
2021
pubmed:
9
4
2021
medline:
23
11
2021
entrez:
8
4
2021
Statut:
ppublish
Résumé
Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of nteroception, emotion, allostasis, and neurodegeneration.
Identifiants
pubmed: 33827935
pii: JNEUROSCI.2578-20.2021
doi: 10.1523/JNEUROSCI.2578-20.2021
pmc: PMC8143206
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4276-4292Subventions
Organisme : NIA NIH HHS
ID : R01 AG057234
Pays : United States
Informations de copyright
Copyright © 2021 Salamone, Legaz et al.
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