Anti-inflammatory activity of 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid in LPS-induced rat model.
2-((3-(Chloromethyl)benzoyl)oxy)benzoic acid
Anti-inflammatory activity
COX
LPS
Rat
Journal
Prostaglandins & other lipid mediators
ISSN: 1098-8823
Titre abrégé: Prostaglandins Other Lipid Mediat
Pays: United States
ID NLM: 9808648
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
18
10
2020
revised:
04
03
2021
accepted:
29
03
2021
pubmed:
9
4
2021
medline:
21
1
2022
entrez:
8
4
2021
Statut:
ppublish
Résumé
Salicylic acid derivate is very popular for its activity to suppress pain, fever, and inflammation. One of its derivatives is acetylsalicylic acid (ASA) which has been reported repeatedly that, as a non-steroidal anti-inflammatory drug (NSAID), it has a cardioprotective effect. Although ASA has various advantages, several studies have reported that it may induce severe peptic ulcer disease. We recently synthesized a new compound derived from salicylic acid, namely 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid (3-CH Rats were induced with LPS of 0.5 mg/kg bw intravenously, prior oral administration with vehicle (3% Pulvis Gummi Arabicum / PGA), 500 mg/60 kg body weight (bw; rat dosage converted to human) of 3-CH After the administration of 500 mg/60 kg bw of 3-CH 3-CH
Identifiants
pubmed: 33831580
pii: S1098-8823(21)00024-1
doi: 10.1016/j.prostaglandins.2021.106549
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106549Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.